Jim has a ghost who died during surgery come to his dreams. Melinda and Jim find that the ghost, a supermodel, cannot cross-over as she wants to save her little sister from suffering the same destiny. Jim's friends are frightened by the crazy events that occur at his house.

Melinda finds that she must stop a ghost who doesn't want to be reincarnated again. Melinda finds out that someone knows her secret. Delia has second thoughts about dinner date.

A body goes missing from the morgue and Melinda searches for the body. When the ghost visits Melinda she finds she needs help from Professor Payne to figure it out.

Melinda helps Ned deal with a ghost who had just put a scare into him. Melinda also helps a ghost who appears to without any clothes on. Delia sees that Melinda is once again talking to herself and Melinda decides it’s time to share her gift with Delia.

Five accidents, and four signs, something else is going to happen. Melinda becomes concerned for the safety of the people she loves when a ghost prophet shows her visions of the future. The fellow Ghost Whisperer, who Melinda doesn't trust is still in Grandview.

While facing dramatic personal changes, Melinda struggles to help a desperate teenage ghost, feeling her gift of being able to talk to the dead is no longer helpful.