Horatio's son goes missing when a prison transport is attacked. Upon learning the identity of Kyle, he is targeted in order to get at Lt. Caine, who must find him before it is too late.

Meanwhile, Ryan causes tension with his former colleagues when he is hired as an expert witness for the defense.

The investigation into a runway model's death leads Horatio to his son and his nemesis.

Kyle's mom shows up in Miami and she is the widowed wife of a billionaire. She wants Kyle back and will do anything to get him back.