The team investigates the deaths of two college students who were in Miami on spring break. The first is a teenage girl found dead on a beach with her neck broken and human bite marks on her legs. The second is a young man found in the bottom of a hotel swimming pool who apparently died before he hit the water.

An explosion in a rundown barn nearly kills Horatio and his crew just after they find a dead man inside, bound with duct tape. The case gets personal for Horatio when he discovers that the leading suspect knew his late brother. Meanwhile, Alexx is shocked to learn that her best friend's husband has been murdered, apparently the victim of a random shooting.