Ben calls Dean and tells him Lisa is in trouble. Dean leaves Sam to investigate a case alone and rushes home to rescue Lisa, however, he’s not prepared for what meets him at the door. Meanwhile, Sam discovers the men that were murdered were all a part of a cruel practical joke played on a female co-worker who went missing.

Still reeling after what happened to Bobby, Dean becomes dangerously obsessed over finding a way to take down Dick Roman. Meanwhile, Sam decides to help a teenage girl look for her father, a hunter who has gone missing. Sam traces his last steps to a truck stop where the help turns out not to be so friendly.

Sam and Dean investigate the mysterious deaths of two LARPers who were playing a game titled Moondoor. The guys are thrilled to discover that the Queen of Moondoor is none other than Charlie.

The Winchester brothers investigate a murder that was apparently caused by a ghost. Sam and Dean discover that the Ghostfacers, Ed and Harry, are already on the case.

Sam and Dean investigate a series of werewolf attacks.