Dick Roman acquires Frank's hard drive that contains sensitive information about the Winchesters and gives it to an unsuspecting brilliant hacker named Charlie telling her she has 3 days to crack the encryptionl or she is fired. Sam and Dean are tipped off that Dick has the hard drive and race to get to Charlie before she breaks the code. Meanwhile, Bobby tries to help the brothers, but his rage towards Dick for killing him starts to get in the way.

When members of a virgin chastity group are abducted, Sheriff Jody Mills asks Sam and Dean for help. The Winchesters go undercover to track down the missing members, but when Dean disappears, Sam and Jody end up having to track him down.

After Dean hears a surprising message on Bobby's phone, he and Sam head out to investigate.

A chance to take out a nest of vampires backfires when the alpha-vamp shows up and turns the tables on Mary and the British Men of Letters, who are doing their best to recruit Sam and Dean.