Sam and Dean are kidnapped by a group of gods, including Kali, Ganesh, and Baldur and held hostage in a small hotel. The gods want to use Sam and Dean as bargaining chips to stop the Apocalypse, but Gabriel shows up and warns them that if Lucifer finds them he will kill them all. Unfortunately, one of the gods turns on the rest and Lucifer appears.

Castiel investigates the mass slaughter of angels and finds a lone survivor and an old friend. Meanwhile, Sam and Dean capture Gadreel, and Metatron begins the ending of his story.

Sam, Dean and Castiel search for Lucifer who, meanwhile, strikes an unlikely deal with a local faith healer named Sister Jo. Asmodeus inches closer to finding Jack.

Sam and Dean continue to collect the pieces necessary to open a rift to the other world in order to save their family. Their latest quest leads them to a Men of Letters bunker from the 1920s and a hungry God from another dimension. Meanwhile, Ketch makes a shocking decision about Gabriel after an unruly encounter with Asmodeus.

Lucifer rules over heaven but things aren’t going exactly as planned, exasperating his first lady, Jo. Sam and Castiel are perplexed by the return of Gabriel. Meanwhile, Dean gets one step closer to finding Mary and Jack.

Gabriel is back and drags Sam and Dean into his plot for revenge on the demigods who sold him to Asmodeus. Meanwhile, Jack's inflating confidence leads to reckless decisions that could put others in harm's way.

Sam, Dean, Castiel and Gabriel must work together if they have any hope of bringing Mary and Jack home. Meanwhile, Rowena’s encounter with Lucifer may alter the outcome of the journey for one of our heroes.

Sam and Dean devise a plan that will save innocent lives. Meanwhile, Jack continues to wrestle with the consequences of his decisions.

Sam finds a clue to Dean’s whereabouts, so he, Mary and Bobby set out to investigate. Castiel imparts some sage advice on Jack, who, still desperate to belong, seeks out a familial connection.