Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable with putting Mary in danger but she insists on going along. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.

After being arrested for the attempted assassination of the President of The United States, Sam and Dean must find a way out of an underground, government-run, detention facility in the middle of nowhere. Determined to find her sons, Mary and Castiel seek assistance from an unlikely source.

A chance to take out a nest of vampires backfires when the alpha-vamp shows up and turns the tables on Mary and the British Men of Letters, who are doing their best to recruit Sam and Dean.

Sam and Dean let Mick Davies tag along on a case as they search for a werewolf. The three men run into Claire Novak, also working the hunt. However, the reunion is short lived after Claire is bitten and the brothers race to find a way to help her before she turns.

Sam and Dean get a lead on Kelly Kline’s whereabouts. Mick drops by the bunker unexpectedly and decides to join the hunt.