The Winchesters investigate a series of crimes where robbers with no criminal past commit suicide after the hold-ups.

Sam and Dean allow themselves to be arrested in order to investigate a series of murders inside a penitentiary. However things get complicated when FBI agent Henricksen shows up to take over their case.

FBI Agent Henricksen finally captures Sam and Dean, but is caught in the middle when a horde of demons descends on the small-town jail to eliminate the brothers.

After Dean's encounter with Castiel, Dean, Sam and Bobby brush up on their biblical lore when they're attacked by the vengeful spirits of people from the Winchesters' past. They're warned it's a sign that someone is trying to break seals which will bring on the apocalypse.