Seven demons, based on the Seven Deadly Sins, are released into the world and the brothers must combat them with the aid of a married Hunter couple.

Sam & Dean track down changelings that are pursuing mothers and their children. A boy they protect bears a strange resemblance to Dean, which at first makes Dean uncomfortable because he once had a one-night stand with the boy's mother Lisa.

The brothers investigate the death of a man who committed suicide in a church. However, Sam is forced to team up with an unexpected ally when Dean disappears with a female demon who is interested in him personally.

The seemingly harmless practices of a group of neighborhood witches goes bad when one of them kills a woman. Ruby offers her assistance... but she has a few secrets of her own.

FBI Agent Henricksen finally captures Sam and Dean, but is caught in the middle when a horde of demons descends on the small-town jail to eliminate the brothers.

Sam, Dean, and Bobby hunt down Lilith and fight her and her demons in a final effort to save Dean's life.