Amara unleashes a dark fog on a small town, causing everyone to go mad. Dean and Sam realize this is a stronger version of the original black vein virus Amara previously unleashed. They team up with the sheriff to protect the town but their old remedy no longer works. Meanwhile, Chuck returns with an interesting proposal.

Amara shows Dean how she’s torturing Lucifer. Worried for Castiel, Dean and Sam come up with a plan to rescue him from Amara’s clutches.

Sam and Dean face their biggest challenge yet. Rowena makes her move.

God comes to a decision about Amara that has direct repercussions for Sam and Dean.

Sam, Dean and Castiel call on Rowena to help keep the evil souls at bay and get an unexpected assist from Ketch.

Sam and Dean investigate the mysterious death of a girl and the disappearance of another.