Sam, Dean and Castiel search for Lucifer who, meanwhile, strikes an unlikely deal with a local faith healer named Sister Jo. Asmodeus inches closer to finding Jack.

Sam and Dean are close to collecting everything they need to open a rift into the Apocalyptic World and possibly rescuing Mary and Jack. The one missing ingredient leads the Winchesters to a black market for religious relics where everything is not always as it seems.