After "helping" Suresh search for more people with special abilities, Sylar's rampage continues with two "heroes" being confronted by the stronger-powered serial killer. Nathan must factor what he's learned from Linderman into difficult decisions that will shape the future, for him, his family, New York City and the world.

Monica starts to exhibit new abilities while working with Micah, Nana, and Damon. Nana is the grandmother of Micah, Monica, and Damon. They all currently reside in New Orleans. Matt asks Molly to locate the man in her dreams. He may be the newest threat to the Heroes. Maya and Alejandro continue their trek to the U.S. Both Claire and her father are suspicious of one another. Angela reveals a lot of her secrets.

Peter travels to Primatech in Texas to destroy the virus, but not everything is what it seems. Hiro continues the pursuit of his father's killer, while Matt pursues the last Company member in the photo. Nikki is reunited with Micah but has bad news, while Maya has to choose to remain with Alejandro, or go with Sylar.

Peter travels to the future and adopts a dangerous ability in order to try to save the world. Meanwhile, Mohinder struggles with his continuing evolution from the formula, and Hiro and Ando re-unite with an old enemy.

As Nathan, Claire, Peter and H.R.G. help Angela uncover her past, she reveals the dark secrets that have haunted her for years. Meanwhile, Mohinder learns of his father’s involvement in a long forgotten government operation.

Everyone bands together to try to stop Samuel from taking the lives of thousands. Peter joins forces with his most unexpected ally to save Emma. Meanwhile, H.R.G.'s life hangs in the balance as he and Claire find themselves trapped underground with oxygen quickly running out. Elsewhere, Hiro starts to come to grips with the decisions he has made and is called into action to help stop a disaster.