On a world where being smart is the equivalent of being a sports star, Quinn is a popular college athlete and finds his double had underhanded dealings with gangsters. Meanwhile, Arturo discovers his late wife is alive on this world and tries for reconciliation after learning she is pressing for divorce.

On a world where everything west of the Mississippi is part of the Nation of Texas, corporate lawyers carry gunslinging ways of the Old West. After Quinn gets mixed up in a showdown, he gains the reputation for fastest draw in San Francisco and tries to prevent the hostile takeover of a family-owned computer company.

On a world where Prohibition was never repealed, Rembrandt's double is famous for fighting crime and corruption. Unfortunately, the trouble starts when the Sliders land in the middle of a wedding, where the groom and bride are from mob organizations.

The Sliders arrive on a world where electric tornadoes have almost completely wiped out the population. They find a secluded village somehow protected from the tornadoes and a dictator that may prevent the team from ever sliding again.

On a world where a group of social misfits have learned to torture people by entering their dreams, Wade becomes a target of the group's leader.

On a world ruled by Egyptian culture, Quinn is used in a life-after-death experiment and thought dead. The others miss the slide when trying to save a woman from a sacrifice and become trapped in a pyramid with a big scarab.

The Sliders track Rickman to a superstitious town. Their search is further complicated when Quinn and Maggie are captured by natives living in a mysterious fog. There, Quinn runs into someone from his past--himself.

The Sliders land on a world where California has been taken over by racists. Rembrandt is captured and placed in a prison camp used to turn non-whites into faceless slaves.