While working in his basement, Quinn Mallory opens the gateway to parallel worlds. For a test run, Quinn invites co-worker Wade Welles and his teacher, Professor Arturo, along. Upon opening the vortex, Quinn uses too much power, which causes the vortex to suck them in along with Rembrandt "Crying Man" Brown, who happened to be driving by Quinn's house. The four arrive on a world that experienced an ecological disaster and will have to survive until the timer hits zero.

On a world where penicillin was never invented, Quinn is mistaken for his double, who is believed to be the cause of a massive epidemic. While he is imprisoned by a health agency, Wade shows signs of being infected and only Arturo can find the cure.

The Sliders arrive on a world that will be destroyed by an asteroid before they are due to slide. Arturo works with Bennish to develop an atom bomb to destroy the asteroid and Rembrandt gets caught up in an end of the world celebration, while Quinn and Wade confront their feelings for one another.

The Sliders arrive in the British States of America, where Arturo's double is plotting to assassinate a prince and take the throne. When the Sliders inadvertently foil the plot, they come into contact with a group of rebels trying to bring freedom to America.

The Sliders are separated on a world where the Hippie movement of the sixties is still alive and the US is at war with Australia. Wade and Rembrandt are mistaken for extraterrestrial prophets at a commune, while Quinn and Arturo race to fix a broken timer and rejoin the others.

On a world where being smart is the equivalent of being a sports star, Quinn is a popular college athlete and finds his double had underhanded dealings with gangsters. Meanwhile, Arturo discovers his late wife is alive on this world and tries for reconciliation after learning she is pressing for divorce.

The Sliders arrive on a world where roles are reversed with women holding the positions of power. Arturo becomes a candidate for the mayoral race in San Francisco, trying to bring about a "men's rights" movement.

Rembrandt has arrived on his dream world, where his double is as popular as Elvis, but has been dead for eight years. As Rembrandt gets to enjoy the fame he's long since wanted, an old enemy plots to make sure he disappears for good.

When the Sliders land on a seemingly ideal world, Wade wins the lottery. But Quinn discovers that the lottery is population control and the winners are killed.

After separating from Ryan and Henry the dog, the Sliders make a rough landing that reopens Quinn's bullet wound. On this world of mysticism and superstition, a witch doctor heals Quinn and has brains on the mind when they can't pay the bill. On the run from bounty hunters, the Sliders only hope is the mysterious Sorcerer, a man who could possibly get them home.

On a world where a biological weapon wiped out most of the male population, Quinn, Rembrandt and Arturo become objects of desire and are imprisoned by the government to be breeders. As they try to escape and regroup with Wade, they find there are others out to capture them.

A lightning bolt strikes the vortex during a slide, damaging the timer and trapping Quinn on the astral plane. Now the Sliders are stranded on a world with 1950s technology and Quinn can not be seen by the others. He tries to get the help from the only one who can see or hear him, a girl that has a history of hearing voices.

On a world where everything west of the Mississippi is part of the Nation of Texas, corporate lawyers carry gunslinging ways of the Old West. After Quinn gets mixed up in a showdown, he gains the reputation for fastest draw in San Francisco and tries to prevent the hostile takeover of a family-owned computer company.

While the Sliders wait to leave a world of violence, Quinn saves a woman named Michelle from her criminal boyfriend, Sid. Sid then goes after the Sliders through the vortex, where they all arrive on a world where San Francisco is a maximum security prison.

Wade witnesses a murder just before the slide, but as the Sliders land on the next world, the same murder is about to occur. This time, Wade intervenes and this gets the Sliders involved with a disgraced federal judge and a United States under martial law.

The Sliders land on a world where San Francisco is a national park dedicated to the preservation of dinosaurs, which is home to a deadly Allosaurus. A bad fall causes Arturo to injure himself and lose the timer. Quinn goes out alone to search for it, while the others hide out from the Allosaurus in a cave.

The Sliders have come to the most unexpected world of all... home. While Rembrandt and Wade use their sliding adventures to kickstart their careers, Arturo steals the timer and claims sliding as his invention. However, Quinn remains convinced they are not home.

Wade literally meets the man of her dreams, Derek Bond, on a world where ten percent of the population possess psychic abilities. It turns out Derek is a psychic and is next in line for the powerful position of Prime Oracle. But the future gets grim fast as Rembrandt and Arturo become prime suspects in a murder that hasn't happened yet.

On a world where Prohibition was never repealed, Rembrandt's double is famous for fighting crime and corruption. Unfortunately, the trouble starts when the Sliders land in the middle of a wedding, where the groom and bride are from mob organizations.

The Sliders arrive on a world where the young are in charge and Wade and Quinn's doubles were married corporate executives. Quinn winds up posing as his dead double and finds questions in his death. Meanwhile, Arturo and Rembrandt find themselves in trouble with the law and face jail time.

The Sliders land in the middle of a strange invasion and Quinn uses the timer to bring down one of the ships. Before barely escaping, the Sliders learn these new villains can slide at will and are soon captured on the next world. They learn their captors are the Kromaggs and are intent on conquering every parallel world.

The Sliders find themselves running into the same people on each new world, one of them being Quinn's former love, Daelin. After encounters on worlds where the Spanish rule America and Daelin is an abused wife, the Sliders arrive on a world where time moves backwards and they are accused of Daelin's murder. Quinn wants to save her, but it could have disastrous results.

The Sliders become involuntarily apart of a human war game where the only winners are the ones that stay alive.

On a world quickly running out of natural resources, Rembrandt meets his number one fan but finds her to be a little too friendly. Meanwhile, Quinn and the others meet Logan, a scientist at Prototronics that's trying to develop sliding. However, they learn her plans for sliding are far from noble.

The Sliders arrive on a world where electric tornadoes have almost completely wiped out the population. They find a secluded village somehow protected from the tornadoes and a dictator that may prevent the team from ever sliding again.

The Sliders arrive on a world just like their own, only time is moving at a rate of twelve years slower than normal. There, Quinn encounters his young double and tries to change an upcoming event in his life, despite the other Sliders' warnings.

On a world where a group of social misfits have learned to torture people by entering their dreams, Wade becomes a target of the group's leader.

The Sliders land on a world with little water and come to the aid of a mysterious young woman whose gift to find water is being exploited by a group of thugs.

On a world of magic and dragons, Quinn is mistaken for a wizard and kidnapped by an evil warlock bent on immortality. Meanwhile, Wade tries to help Rembrandt's love troubles with a love potion, but it backfires and makes Rembrandt fall in love with her.

After barely escaping a world engulfed in flames, the Sliders now find themselves in a Los Angeles dependent on the sale and production of oil. Unfortunately, they learn they've brought along a piece of the fire from the last world and that it has a mind of it's own.

On a world where the American government is a monarchy, Rembrandt is mistaken for his double and discovers that he is about to be a father of royalty. The only problem is, on this world, it's the men who give birth to children.

On a world where the legal system is in the form of televised game shows, Quinn is arrested, tried and sentenced to death for the crimes of his double.

The Sliders land on a world where the human race was wiped out by robots. Quinn and Rembrandt are captured by the robot's demented creator and are going to be used in a mind-transfer experiment.

On a world where people are enticed by consumerism and giant malls in the sky, the Sliders get jobs as mall employees to find the mother of an abandoned child. Arturo is a reluctant Santa, Rembrandt and Wade his elves while Quinn gets an administrative job. Meanwhile, Wade faces some strong emotions when she meets her sister and father.

On an over-worked world with an uptight population, Arturo is thought to be a fracture and is sent to a fantasy camp for a form of relaxation. When the others find him, they see he has been brainwashed into thinking he is a great detective on the trail of a Jack the Ripper-like murderer.

On a world ruled by Egyptian culture, Quinn is used in a life-after-death experiment and thought dead. The others miss the slide when trying to save a woman from a sacrifice and become trapped in a pyramid with a big scarab.

The Sliders arrive in a small community, where the citizens are all young and fearful of outsiders. They don't expect much trouble, until they uncover a deadly secret.

Things don't look good for the Sliders when they slide to a world that's about to be eradicated by a rogue pulsar. Soon they discover that this world has been developing sliding technology and pool their resources with the U.S. government in a race to escape to a parallel Earth.

Quinn and Maggie return to her world with Earth Prime's coordinates stored in Jensen's timer. As Wade makes the final list for those who can slide to safety, Arturo races to modify the new timer to slide more people. Unfortunately for them, an unexpected danger lurks the base and one Slider will not make it to the next world.

The Sliders arrive on a world where a strange bacteria transformed the inhabitants into flesh-eating zombies. When Quinn is bitten, he begins to turn into one of them.

A creature embeds a parasite in Maggie just before the slide, which takes the Sliders to a world where young adults are used in a mandatory organ-donor program. The others will have to find Maggie before she finds the perfect mate and lays her eggs.

Wade and Rembrandt recall their slide to a world plagued by earthquakes and populated by primitive people. Wade falls into a deep chasm and Quinn goes to rescue her, while Rembrandt learns of Arturo's illness.

The Sliders track Rickman to a superstitious town. Their search is further complicated when Quinn and Maggie are captured by natives living in a mysterious fog. There, Quinn runs into someone from his past--himself.

While on vacation, Quinn and Rembrandt get mixed up in an illegal snake deal and find themselves stuck in the middle of no where surrounded by deadly snakes. Meanwhile, Wade and Maggie get involved with a shady man in their search for the others.

The Sliders' chase for Rickman takes them back to the world they helped colonize, the New World. Only they find that the colonists are being hunted by a hungry Tyrannosaurus Rex.

Wade falls under the spell of a rock band's charismatic lead singer, who is really a vampire and looking to use Wade to get the timer. Meanwhile, the others try to track down Rickman.

The Sliders track Rickman to a world where a mad scientist has been experimenting with genetic testing and has created a race of human hybrids.

After three months and ten worlds of searching for Wade and Rembrandt, Quinn and Maggie finally reach Earth Prime, only to find it under Kromagg control. Quinn and Maggie manage to rescue Rembrandt from a Kromagg prison, but Quinn is captured and learns the shocking truth about his family.

Quinn, Rembrandt and Maggie land on a world where the United States is run by the Oracle, a blend of fundamental beliefs and right-wing conservatism. Followers trade their wealth and possessions in return for passage to a nirvana world, but the Sliders discover the Oracle's portal is a deadly sham.

The Sliders slide into a Kromagg weapons-testing area and Maggie saves the life of the Kromagg commander, Kromanus. While Maggie tries to get the timer back from him, Quinn and Rembrandt discover a Kromagg weapon designed to eradicate humans.

The Sliders arrive on a world where virtual reality is a normal part of life. After Maggie is injured in an explosion, she awakens in a hospital to find they have missed the slide. The only way to go is to build a new timer, but is everything what it seems?

After landing in a San Francisco completely devoid of people, the Sliders go to Quinn's house and discover Quinn's double accidentally slid everyone to a parallel world a few years ago. Both Quinns, Maggie and Rembrandt travel to the world where everyone was sent and rush to set things right.

The Sliders track down Quinn's long lost brother, Colin, to a Amish-type Earth. Quinn convinces Colin they are brothers and to slide to find their true home. But on the next world, a double of Colin's former love takes advantage of him and involves him in a scam to steal cryogenically frozen bodies.

On a world where drug use is mandatory, Maggie and Colin are dosed with mind-altering chemicals. Rembrandt and Quinn have to find a way to save them and outrun the Drug Empowerment Administration.

Acid rain forces the Sliders to stay in the Chandler Hotel. Colin claims to have seen a ghost and the timer is mysteriously stolen.

When Quinn and Colin finally access the coordinates to their home, the Sliders expect it to be their last slide. Instead, they arrive inside a security compound on a barren world, where humans and Kromaggs are fighting for survival.

On a world raided by Kromaggs for natural resources, Rembrandt falls in love with a doctor who can save a critically injured Quinn. Problem is, Maggie learns this doctor collaborated with the Kromaggs and is on the run from the British secret service.

The Sliders land on a world where California has been taken over by racists. Rembrandt is captured and placed in a prison camp used to turn non-whites into faceless slaves.

The Sliders arrive on a Kromagg training camp, where half-human Kromaggs hunt humans. Quinn tries to convince one of them to help free a captured Colin.

The vortex splits the Sliders up and they only have two hours before the slide. Quinn tries to contact the others by appearing on the world's most popular show: Lipschitz Live. Meanwhile, Colin is mistaken for his double and betrothed to a woman as part of a business deal.

The Sliders discover a woman escaping from a Kromagg breeder camp and take her to her Earth, where an anti-Kromagg virus proves deadly for her half-Kromagg son.

A sliding mishap separates the Sliders into two groups on a world divided by the computer-savvy and ruthless scavengers. To reunite, they'll have to battle the scavengers and unite a young couple who fell in love on the internet.

The Sliders accidentally slide out with Maggie's double, leaving Maggie stranded on an American military base where deadly experiments are performed on pilots. Meanwhile, the Sliders arrive on a world that outlaws technology.

When the Sliders step into the Chandler Hotel, they are surprised to learn they have been turned into computer data. There they meet the owner of the hotel, Archibald Chandler, who will not allow them to leave.

Colin is wounded on a Wild West Earth and separated from the others. While he is nursed back to health by a widow and her daughter, the others search for him and find an old foe.

The Sliders arrive on a world where clones are harvested for spare body parts. Quinn's double is blinded in a lab accident and when Quinn tries to help, he is mistaken for a clone. Meanwhile, the others inadvertently rescue the clone, which Colin tries to teach the importance of family and sacrifice.

The Sliders arrive in what is literally the happiest place on Earth. But in this small community, a little girl witnessed her grandfather leap into a mysterious chasm and begins to feel an overwhelming sorrow. Worse yet, it soon spreads to Rembrandt and Maggie.

A rough slide separates Quinn and Maggie from Rembrandt and Colin for a brief time. Soon after they reunite, Quinn and Maggie become seriously ill and appear to be dying of old age. Unable to help them themselves, Rembrandt and Colin will have to rely on someone claiming to be Quinn and Maggie's son.

With nearly a month until their next slide, the Sliders find themselves extremely bored on a dull world. While the others get jobs, Rembrandt dives into a sci-fi book that bears more than a resemblance to their lives. When the Sliders track down the author, they learn he came from Quinn and Colin's home world.