Things don't look good for the Sliders when they slide to a world that's about to be eradicated by a rogue pulsar. Soon they discover that this world has been developing sliding technology and pool their resources with the U.S. government in a race to escape to a parallel Earth.

Quinn and Maggie return to her world with Earth Prime's coordinates stored in Jensen's timer. As Wade makes the final list for those who can slide to safety, Arturo races to modify the new timer to slide more people. Unfortunately for them, an unexpected danger lurks the base and one Slider will not make it to the next world.

The Sliders arrive on a world where a strange bacteria transformed the inhabitants into flesh-eating zombies. When Quinn is bitten, he begins to turn into one of them.

A creature embeds a parasite in Maggie just before the slide, which takes the Sliders to a world where young adults are used in a mandatory organ-donor program. The others will have to find Maggie before she finds the perfect mate and lays her eggs.

The Sliders track Rickman to a superstitious town. Their search is further complicated when Quinn and Maggie are captured by natives living in a mysterious fog. There, Quinn runs into someone from his past--himself.

While on vacation, Quinn and Rembrandt get mixed up in an illegal snake deal and find themselves stuck in the middle of no where surrounded by deadly snakes. Meanwhile, Wade and Maggie get involved with a shady man in their search for the others.

The Sliders' chase for Rickman takes them back to the world they helped colonize, the New World. Only they find that the colonists are being hunted by a hungry Tyrannosaurus Rex.

Wade falls under the spell of a rock band's charismatic lead singer, who is really a vampire and looking to use Wade to get the timer. Meanwhile, the others try to track down Rickman.

After three months and ten worlds of searching for Wade and Rembrandt, Quinn and Maggie finally reach Earth Prime, only to find it under Kromagg control. Quinn and Maggie manage to rescue Rembrandt from a Kromagg prison, but Quinn is captured and learns the shocking truth about his family.

Quinn, Rembrandt and Maggie land on a world where the United States is run by the Oracle, a blend of fundamental beliefs and right-wing conservatism. Followers trade their wealth and possessions in return for passage to a nirvana world, but the Sliders discover the Oracle's portal is a deadly sham.

The Sliders slide into a Kromagg weapons-testing area and Maggie saves the life of the Kromagg commander, Kromanus. While Maggie tries to get the timer back from him, Quinn and Rembrandt discover a Kromagg weapon designed to eradicate humans.

The Sliders arrive on a world where virtual reality is a normal part of life. After Maggie is injured in an explosion, she awakens in a hospital to find they have missed the slide. The only way to go is to build a new timer, but is everything what it seems?

After landing in a San Francisco completely devoid of people, the Sliders go to Quinn's house and discover Quinn's double accidentally slid everyone to a parallel world a few years ago. Both Quinns, Maggie and Rembrandt travel to the world where everyone was sent and rush to set things right.

The Sliders track down Quinn's long lost brother, Colin, to a Amish-type Earth. Quinn convinces Colin they are brothers and to slide to find their true home. But on the next world, a double of Colin's former love takes advantage of him and involves him in a scam to steal cryogenically frozen bodies.

On a world where drug use is mandatory, Maggie and Colin are dosed with mind-altering chemicals. Rembrandt and Quinn have to find a way to save them and outrun the Drug Empowerment Administration.

Acid rain forces the Sliders to stay in the Chandler Hotel. Colin claims to have seen a ghost and the timer is mysteriously stolen.

When Quinn and Colin finally access the coordinates to their home, the Sliders expect it to be their last slide. Instead, they arrive inside a security compound on a barren world, where humans and Kromaggs are fighting for survival.

On a world raided by Kromaggs for natural resources, Rembrandt falls in love with a doctor who can save a critically injured Quinn. Problem is, Maggie learns this doctor collaborated with the Kromaggs and is on the run from the British secret service.

The Sliders land on a world where California has been taken over by racists. Rembrandt is captured and placed in a prison camp used to turn non-whites into faceless slaves.

The Sliders arrive on a Kromagg training camp, where half-human Kromaggs hunt humans. Quinn tries to convince one of them to help free a captured Colin.

The vortex splits the Sliders up and they only have two hours before the slide. Quinn tries to contact the others by appearing on the world's most popular show: Lipschitz Live. Meanwhile, Colin is mistaken for his double and betrothed to a woman as part of a business deal.

The Sliders discover a woman escaping from a Kromagg breeder camp and take her to her Earth, where an anti-Kromagg virus proves deadly for her half-Kromagg son.

A sliding mishap separates the Sliders into two groups on a world divided by the computer-savvy and ruthless scavengers. To reunite, they'll have to battle the scavengers and unite a young couple who fell in love on the internet.

The Sliders accidentally slide out with Maggie's double, leaving Maggie stranded on an American military base where deadly experiments are performed on pilots. Meanwhile, the Sliders arrive on a world that outlaws technology.

When the Sliders step into the Chandler Hotel, they are surprised to learn they have been turned into computer data. There they meet the owner of the hotel, Archibald Chandler, who will not allow them to leave.

Colin is wounded on a Wild West Earth and separated from the others. While he is nursed back to health by a widow and her daughter, the others search for him and find an old foe.

The Sliders arrive on a world where clones are harvested for spare body parts. Quinn's double is blinded in a lab accident and when Quinn tries to help, he is mistaken for a clone. Meanwhile, the others inadvertently rescue the clone, which Colin tries to teach the importance of family and sacrifice.

The Sliders arrive in what is literally the happiest place on Earth. But in this small community, a little girl witnessed her grandfather leap into a mysterious chasm and begins to feel an overwhelming sorrow. Worse yet, it soon spreads to Rembrandt and Maggie.

A rough slide separates Quinn and Maggie from Rembrandt and Colin for a brief time. Soon after they reunite, Quinn and Maggie become seriously ill and appear to be dying of old age. Unable to help them themselves, Rembrandt and Colin will have to rely on someone claiming to be Quinn and Maggie's son.

With nearly a month until their next slide, the Sliders find themselves extremely bored on a dull world. While the others get jobs, Rembrandt dives into a sci-fi book that bears more than a resemblance to their lives. When the Sliders track down the author, they learn he came from Quinn and Colin's home world.

After experiencing a rough slide, Rembrandt and Maggie see Colin is nowhere to be found. More disturbing, they meet a stranger claiming he is Quinn Mallory. Rembrandt and Maggie learn too late that this is all apart of an evil genius' desperate plan to save his life.

Diana tries using a university lab to find a way to separate Quinn and Mallory, which leads to her first encounter with her double, a struggling single mother. Meanwhile, Mallory experiences violent flashbacks from Quinn's life.

The Sliders arrive in a barren wasteland, where the timer is inoperable. Worse yet, they find themselves forced to take part in a never ending battle between Kromaggs and soldiers from Quinn's home world, who are guarding a mysterious bunker.

The Sliders arrive on a small island, with a very sick Maggie in tow. While looking for help, Rembrandt, Mallory and Diana meet the monks of a secluded monastery. Reluctantly, the monks allow them to stay and give Maggie medical attention. But the Sliders soon learn the monks have a secret and won't allow them to leave.

Just before sliding out and escaping a small army, Mallory is shot with a laser beam and paralyzed. His only chance of walking again lies in a group of spiritual healers, but their cure could be much worse than being paralyzed.

After trying to buy a candy bar, Maggie is kidnapped by a corporate conglomerate that uses data codes to control commerce.

On a world where tabloid journalism is in place of real news, a photo suggests Maggie is having an affair with the President. But the President's advisers decide to exploit it in order to distract attention from a war with Switzerland.

The Sliders arrive on a world where Prohibition still exists, only it was caffeine that was outlawed. They meet a nightclub owner whose lover was murdered by a gang dealing in bootleg coffee.

The Sliders arrive on a world where Maggie's double was a heroic astronaut and loved by the public. When she is mistaken for her double, the public gets excited. After being kidnapped by the mysterious Leader, Maggie is taken by the government where she must confront her father.

The Sliders arrive on a world where combustion engines were outlawed by the government due to pollution. But a biker gang is fighting to keep their engines and Mallory falls for the gang's sexy leader.

Rembrandt experiences a strange dream in which Wade is trying to contact him and bring him to her. The others have their doubts until a spatial fold opens before them. On the other side, they find Wade is somehow being used in a plan to attack Kromagg Prime.

The Sliders arrive at a mental institution in the middle of an unusual riot. Rembrandt and Maggie escape capture, but Diana and Mallory get left behind. While Mallory has managed to pose as a doctor, Diana is mistaken for a patient and undergoes the process of her brain being remapped.

The Sliders arrive on a world where millions play in highly realistic arcade simulations. Rembrandt and Mallory take part in separate simulations, until they discover Maggie and Diana have been forced to play characters in these simulations, where each "death" experienced is real.

A malfunctioning timer deposits the Sliders underwater in the Pacific Ocean. A merchant ship picks them up, but is taking them out of their sliding radius and decreasing the likelihood of a safe slide. Their only chance is to join up with a pirate crew to get back to California.

The timer continues to malfunction, giving the Sliders rougher slides than usual. To fix it, the Sliders need to get ahold of a gem, even if it means stealing.

The Sliders are lost in the desert, but happen upon an archaeological dig. They soon find, however, that the dig is unearthing a buried Los Angeles and that the locals consider Rembrandt a deity.

The Sliders confront Dr. Geiger again, in a collapsing dimension full of innocent victims.

The Sliders arrive in the middle of a rally, surprisingly being held in their honor. They learn they are the subjects of a religion called Slidology, founded by a man with psychic abilities. He has been following their adventures and warns that on their next slide, they will all die.