In the pilot, much to his chagrin, Bernie and Wanda are forced to take care of his sister's three children, Vanessa, Jordan, and Bryanna since she can no longer take care of them anymore.

Bernie's desperate to get away to Vegas with his frineds, but Bryana's birthday and the germ infested children that it causes make it a difficulty.

When Wanda plans a play date for a group of kids, Bernie ends up winning over the moms for the afternoon and becoming defensive about his masculinity.

Bernie and Wanda bring the kids to church to discipline them, but Bernie ends up being the immature one. Later on, the Bishop and Deacon show up at Bernie's house during his poker night and suggest that Bernie allow them to use his house for bible study.

Wanda spends time with the kids and considers having a child with Bernie.

Bernie becomes concerned when he begins to see the classic signs that old age is catching up with him. He's forgetful, has aches and pains, and is finding gray hairs in, uh, unwanted places. When a panic attack sends Bernie to the Emergency Room after an argument with the kids, he decides to not let the kids send him to an early grave. He fights back and begins trying to act young again. He blasts his music and nags his friends for not staying up all night to play poker with him.

Bernie only makes matters worse however when all his ""young"" activities take their toll on his mind and body. When Bryana asks Bernie to play in her Father-Daughter Basketball tournament at school, he complains, saying that he is just too old to play. When he gets to the game though, he realizes that he should be playing and joins in. Although he gets hurt playing, Bernie realizes that being old doesn't mean stopping your life.

When someone breaks into the Mac house, Bernie realizes how vulnerable his family is and turns the house into a high-security compound. Bernie is reminded by his friends of all the crime that happens outside of the home and drives his family crazy with his overprotectiveness.

Impressed by the behavior and talents of another family's kids, Bernie cracks down on his own with a program of constant studying.

After hearing Bernie use inappropriate language at home, Bryana goes to school and repeats it—much to the horror of her teacher. Soon after, a social worker shows up at the house to discuss Bernie's hostility problems.

Bernie is concerned that the kids are exposed to mature subjects.

When Kelly's girlfriend throws him out, Bernie lets him stay at the house.

It's Bernie who acts like a kid when Wanda teams with him in a charity golf tournament. Bernie sees it as a grudge match against the host, Matt Damon, who has been claiming he consistently outshot ""Mac Man"" while they were filming Ocean's Eleven. Bernie savors the thought of beating the Oscar winner in public—but his confidence wavers when he learns that Damon's warriorlike playing partner in the best-ball event is Lucy Lawless.

Bernie is delighted that the kids are in a carpool because it means he will only have to drive them to school two days a week. The delight is short-lived when the carpool becomes more complicated. Jordan teases one of the boys in the car, so Bernie makes Jordan set up a playdate with him. Eventually the boy starts blackmailing Jordan to be his friend, and the boy's father won't stop bothering Bernie.

Vanessa is slow to invite Bernie to a father-daughter dance, but quick to treat him like a stranger once there.

Don Rickles plays a neighbor who dispenses some unorthodox advice when Bernie is told he has high cholesterol. Though it's a sore shoulder and badgering from Wanda that sends Bernie to the doctor, he comes away sore at the physician for weighing him down with bad news. The problem can be controlled through diet and exercise, but that would mean avoiding the finer things to which Mac is accustomed... like fries from Royal Burger. But neighborly Don Rickles suggests that stress is the real problem, and what causes stress? Why, dieting, of course! And that's the case Bernie presents to an incredulous Wanda.

Chris Rock and Jay Leno guest star, as Bernie takes a long-standing grudge against Rock all the way to The Tonight Show. Upset after seeing Rock get preferential treatment at a doctor's office, Bernie's blood boils even more when his poker buddies fall all over his fellow comic, who drops by to tell Bernie that they will be co-hosting an awards show. That's not cool with Bernie, who maintains that back in their early days as stand-ups, Chris once told a joke on stage that Bernie had told him just moments before. The situation comes to a head when they're booked on Leno, who's unaware of the rift between the two.

Tired of having to run to the store all the time for the kids, Bernie Mac's friends introduce him to Cost Depot. At first this solution is so simple/fun but it soon gets very addicting.

Jordan tries out for the basketball team, but the coach decides he is better suited for gymnastics -- as a ribbon dancer. Meanwhile, Wanda coaches Bryana's soccer team and turns her into a lean, mean soccer machine.

When Bernie lands the dramatic lead role of a stroke afflicted former track star, he has a hard time convincing everyone he has the chops to be a serious dramatic actor and reaches out to Angela Bassett for acting advice. Since Bernie is working and cannot care for the kids after school, Wanda must put the younger kids into daycare at her work. Upset at being stuck with a bunch of babies, Jordan leads a child rebellion where the kids escape daycare and wreak havoc on the office. Meanwhile, Vanessa pretends to be poor, so that Teri, a girl at school, will like her. But the plan backfires when Teri finds out that Vanessa is lying and that she is really Bernie Mac's niece.

Bernie finds out that Jordan has been getting haircuts with Wanda and the girls at a beauty salon and decides it's time to take him to Bernie's favorite barbershop downtown so Jordan can learn to be one of the guys. There they talk sports, politics, community and most importantly -- smack. But things backfire when Jordan's first attempt at smack-talking hits a nerve with Earl, the barbershop owner, who throws the two out of his shop. Meanwhile, the girls bond with Wanda when they team up to figure out how to change the batteries in the incessantly beeping home smoke detectors.

Jordan enters the school spelling contest. Bernie gives him a little advice that humor can help him overcome his fear. But his material proves that Jordan has no place in the comedy business.

The family heads to San Diego for a nice relaxing family vacation. But it's not the kids who have a problem relaxing, it's Bernie. He jumps on the last flight to Las Vegas to meet the boys for some gambling and debauchery. While in Vegas he meets up with boxer Sugar Shane Mosley, but it's Wanda who throws the punches.

Bernie is tired of living in a child-friendly house and having to give up all of his favorite things because of the kids. When the studio gives him a motorcycle and Wanda suggests that he give it to charity because it is unsafe, he puts his foot down and decides to keep it until he crashes, passes out and sees what the Mac house would be like without him. When he comes to, he realizes that Wanda is right, and he child-proofs everything in the house and becomes over-protective of the kids. Meanwhile, Jordan is caught trying to sell Bernie's girlie magazines to the boys at school and Bernie and Wanda are called into another meeting with Father Cronin.

Psychologist Dr. Phil makes a house call in Bernie's confessional. He counsels Bernie on how to deal with an angry Wanda, who feels left out after Bernie and his buddies bring a woman, Lynette, into their group. Meanwhile, the kids find where Bernie hides all of their dangerous toys and end up almost killing each other to keep the secret.

Bernie's agent Jerry Best takes Jordan to his office on national "Take Your Child to Work Day," and Jordan lands a commercial for the designer knock-offs store, "Magic Malvert's." But when they threaten to fire Jordan, Bernie steps in and is forced to do the commercial. Bernie goes before the American Idol judges in his confessional and they critique his performance in the commercial.

Bernie catches Jordan looking at his men's magazines and playing provocative video games, so Wanda tells him it's time for Jordan to learn about the ""birds and the bees."" Bernie is having trouble getting the words out, so he stops by the Playboy Mansion to get advice from the expert, Hugh Hefner. When Jordan thinks he got a girl pregnant by kissing her, Bernie realizes it's time for the talk.

Bernie's birthday is here and the family does not notice and Bernie begins getting jealous about an old lady shocking him with a stun gun, seeing a kid celebrate his birthday at Jungle Garden and getting locked out. Guest appearances by George Clinton, Daniella Monet and Jill Talley.

Vanessa confronts Bernie for looking through her things; Bernie buys security cameras to see what the family's doing, which more he bargained for. Guest appearance by Snoop Dogg.

Jordan wants to be more popular in school, so Bernie teaches him to gamble, but the trick soon backfires. Wanda's birthday is coming up, and Bernie searches for a rare cognac-colored diamond.

Vanessa's new boyfriend is 18 years old, and has a child by a former girlfriend; Bernie confronts Vanessa about her new boyfriend and gets under her skin about it; Bernie reveals to Wanda that he thinks Vanessa is having sex.

Bernie is happy that Vanessa has joined the Spirit Squad, until he sees the racey costumes and provocative routines. Jordan enlists Bryana and her friends to help him sell a product.

When Jordan develops a crush on a girl, Bernie teaches Jordan how to be a "player". Vanessa wants to attend a hip-hop concert.

Bernie wants to encourage Vanessa's burgeoning musical talent. Guest appearance by Isaac Hayes.

Bernie feels that Jordan is ready to walk home from school by himself, but his walk home days are over after Jordan and his friends pick on a crabby neighbor. Vanessa has a wardrobe malfunction while swimming.

Berine better put his money where his mouth is when he agrees to Charles Barkley's bet that he will beat Bernie's time in a 10K charity race.

After several failed attempts, Bernie and Wanda realize that making a baby is harder than they thought, and Wanda begins to question their fertility.