Jake's grandfather is due to be sworn in as a citizen of the United States of America, but during the ceremony everyone is shocked to discover that Prime Evil has stolen the Statue of Liberty. The Ghostbusters must rush to save the day.

When Prime Evil sends Fangster to retrieve the Aztec Medallion, the Headless Horseman of Sleepy Hollow, a former hench-ghost of Prime Evil arrives at the Ghostbusters Ghost Command warning them of the danger. But can they trust him?

When the other-dimensional Invertroids begin capturing people through mirrors the Ghostbusters join forces with Jessica's uncle John Guardian in order to defeat them. But for the Ghostbusters to prevail a great sacrifice has to be made.

When a young boy named Copernicus Randall sees Fangster in the moon through his new telescope. The Ghostbusters must find out why Prime Evil is trying to prevent the young boy from looking into the stars. They discover the truth in the future.

When Prime Evil discovers mole creatures living in underground caves with an entrance at the North Pole he and Apparitia see an opportunity to overthrow the Earth. Belfry and the Ghostbusters attempt to stop Prime Evil and convince the mole-like people that they are friends.

Prime Evil steals the futuristic Megalaser device and hides it in the center of the earth prompting the Ghostbusters to retrieve it. However, when they arrive they discover that Prime Evil's Golem warriors have overthrown the peaceful inhabitants who dwell in the depths below.

Jessica, Futura and the Ghostbusters travel to China to discover why the Sleeping Dragon has awoken and is turning people into stone. When they arrive Jake and Eddie are turned to stone, and will only be freed along with all the other people if Jessica, Futura and Tracy agree to compete against the Dragon's warriors.