A death row inmate asks for Booth's help to prove his innocence before he is scheduled to be executed. Booth agrees and asks Brennan and her team to help him out.

After digging up the skeletal remains of a young girl, the investigation points to a convicted serial killer on death row. The team follows cryptic clues that lead to another body, an accomplice, and a victim who may still be alive.

The notorious serial killer, Howard Epps, sets his prison cell on fire as part of a daring prison escape. Brennan is his target and her entire team is placed in danger.