Michael Mosley has set himself a truly ambitious goal: he wants to live longer, stay younger and lose weight in the bargain. And he wants to make as few changes to his life as possible along the way. He discovers the powerful new science behind the ancient idea of fasting, and he thinks he's found a way of doing it that still allows him to enjoy his food. Michael tests out the science of fasting on himself - with life-changing results.

Transplant surgery has now reached incredible heights, from achieving full face transplants to growing organs in the lab. This Horizon Guide looks back at the extraordinary odds doctors and patients have had to overcome to achieve these amazing breakthroughs. What we now take for granted has been a hard won struggle, both for the patients who were willing to gamble their lives and the doctors who faced ethical and medical dilemmas in the name of progress. Michael Mosley looks through the Horizon archive, identifying the key turning points for transplant surgery to explore how far science can go in its bid to prolong life.

Michael Mosley explores the latest science about how our personalities are created - and whether they can be changed.

Despite appearances, Mosley is a pessimist who constantly frets about the future. He wants to worry less and become more of an optimist.

He tries out two techniques to change this aspect of his personality - with surprising results.

And he travels to the frontiers of genetics and neuroscience to find out about the forces that shape all our personalities.

To celebrate its 50th birthday, Horizon invites the public to play a role in tackling the greatest challenges facing science today. This special episode of Horizon launches the £10 million Longitude Prize 2014 - a prize developed by Nesta, with Technology Strategy Board as funding partner, to find solutions to a new scientific challenge.

Michael Mosley investigates the alleged danger in eating red and processed meat, and does a one month test on himself, doubling his meat intake.

Dr Michael Mosley seeks to establish the truth about meat. Every year, humans raise and eat 65 billion animals - nine animals for every person on the globe. In this eye-opening documentary, Michael examines the impact that this is having on the planet and finds out what meat eco-friendly carnivores should be buying. Is it better to buy free-range organic or factory-farmed meat? The answers are far from obvious.

Dr Michael Mosley and Professor Alice Roberts investigate if male and female brains really are wired differently.

Michael Mosley investigates the dramatic rise in e-cigarettes. They're everywhere these days, but what does the latest scientific research on them reveal? Michael reveals what e-cigarettes are really doing to your health. Are they really better for you than cigarettes? What is actually in them? Is passive vapour harmful? And can they really stop you from smoking? Michael meets some of the scientists around the world studying them, asks a group of volunteers to try to give up smoking regular cigarettes using them, and even takes up 'vaping' himself, smoking an e-cigarette every day for a month to see the effects on his own health - no easy task for such a committed non-smoker.

Investigating the scientific facts and figures behind the biggest public health crisis in living memory as a new coronavirus takes an unprepared world by storm.

Dr Chris van Tulleken, Dr Hannah Fry and Michael Mosley examine the latest research and explore some of the big questions about the new coronavirus and the pandemic it has created.