The sisters must find and train the 'Chosen One' to vanquish a powerful evil witch that could destroy the Charmed Ones.

A band of knowledge-stealing warlocks hunt down a young man who uncovered the location of one of the greatest sources of power in the world. Meanwhile, Prue has her hands full with Jack Sheridan.

The sisters must face and destroy the demon that was responsible for their mother's death 20 years ago. In the process, they uncover a chapter of their mother's life that they never knew about - one that disturbingly mirrors Piper's current relationship with Leo.

An assassination attempt on the sisters' lives forces Prue to go undercover as the woman who tried to kill them, known as Ms. Hellfire. While undercover, she becomes romantically involved with the man who hired the original Ms. Hellfire.

A demon named Drasi steals Cupid's ring, which brings couples together. Now Cupid must convince the Halliwells to help him get it back before Drasi breaks all of the relationships, thus killing Cupid.

The sisters must find a way to vanquish a ghost who is intent on killing all of the men in a family line, including the last male, a baby named Matthew.

When Piper contracts a life-threatening tropical virus that leaves her in intensive care, and to try to save her life, Prue and Phoebe cast an 'awakening' spell. However, since the spell was used for personal gain, the sisters can no longer sleep, and Piper's sickness spreads into an epidemic as a direct consequence. Meanwhile, Prue quits her job at Bucklands and Phoebe enrolls in university.