As the MPU moves into new offices, which comes with new boss Inspector Hollis Braun, a call comes in reporting the disappearance of an entire city bus full of students on a field trip. The team utilizes a father who tried to stop the kidnapping, as Jason reaches out to an old colleague for assistance in the search.

The MPU searches for a homeless female teen that disappeared after running away from home and living in Philly's Gayborhood. Kemi is hit especially hard as the team races to find and rescue the missing teen. Jason and Nikki spar over his continued investigation into the car bombing.

The MPU searches for a kidnapped tough-as-nails neighborhood watch captain. Jason enlists Wayne's help investigating the car bombing. Mike is concerned Nikki is keeping secrets from him.

The MPU is on the case when a young boy claims his father was abducted by aliens as they were stargazing at a remote campsite. Jason and Nikki enlist Mike's help in getting access to Braun's computer files. Kemi and Helen partner up and venture out into the field.

When Nikki suddenly goes missing, MPU bands together and discovers that Raina, a criminal who Nikki put away, has escaped and is out for vengeance.

As the MPU struggle to adjust in the wake of tragedy, they are forced to jump into action when a muralist goes missing after painting a piece on a local rooftop; the missing person's mother reveals that he was scheduled to donate his rare bone marrow to his dying brother, who needs surgery within the next 48 hours in order to survive.

When a young woman is kidnapped and locked away to freeze to death, the MPU suspects her boyfriend or his father might know more than they're letting on. Meanwhile, Wayne uses her connections to try and get a job at the MPU, and Kemi is put in a dangerous situation while on the case.

When a brewery foreman is kidnapped after arguing with his CEO over safety violations, MPU finds evidence that suggests that the victim was taken by competitors over a stolen beer formula. Also, Bennett’s ex, who is also Houston’s step-son, threatens to make her life hell for interrogating his client without representation.