In 1972 Mi'kmaq Annie Mae Pictou Aquash answers a call by the American Indian Movement (AIM) to go to Washington to force the government to honor its treaty obligations with Indigenous people. Tensions rise, and the activists make a disturbing discovery.

Annie Mae risks her life to join a dangerous occupation in South Dakota. The Movement is embraced by Hollywood, the government secretly infiltrates AIM at the highest levels, and Annie Mae makes a dangerous decision in her personal life.