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Three patients come to the emergency department, all with similar symptoms; Frank's old university friend is admitted; Bart returns looking for a job; Eve plans a trip to Europe; and Von is made the transitional-care nurse.

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The victim of a brutal beating hides a devastating secret that puts the ED team in danger. Gabrielle is forced to face her past when Frank conducts interviews for a new ED doctor. An OCD patient is so desperate to get his hands clean that he uses a toxin that may kill him.

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The hospital has a damages suit launched against it and Director of Medicine, Oliver Maroney is on the warpath; he wants to know who a deceased patient's wife that her husband died due to hospital negligence. Was it Frank? Erica has to nurse a patient who seems intent on making Erica's life a misery. Frank and Dan's attitudes to a patient change when they learn he deliberately caused the accident that led to his amputation. A Mr. Fixit, James Byrne, arrives in the ED. While he is repairing equipment James will make a play for Erica. Mike and Laura's relationship continues to improve while they wait for Simon to undergo dialysis. But Simon's condition worsens. He's in end stage renal failure now. Meanwhile, its Dan's first day on the job since he began interferon therapy and he's beginning to exhibit symptoms of irritability, vagueness and fever. When pushed Dan reveals the truth to Gabrielle but asks her not to tell anyone else, especially Erica.

An afternoon at the ice hockey turns ugly for Jack, Erica, Gabrielle and Heath when a fight breaks out between a player and a spectator with devastating consequences for those around them. While administering another round of chemo to Ann-Maree, Von tries her best to convince the frightened woman that she needs to be honest about her condition for both her sake and Bart's. Charlotte and Dan are given a lesson in the unhealthy lengths some people will go to for love. Steve Taylor returns to work at All Saints.

In the 2007 Series Finale cliff-hanger, Frank and Dan treat a 15-year-old girl whose only chance of survival is a heart transplant. Mike, Charlotte, Erica and Gabrielle fight to save the life of a patient badly injured in a construction accident. Bart persuades Ann-Maree to come in for follow up tests to determine whether or not her cancer has spread. And none of them are aware that the day is about to take a turn for the worse.