Bob Parkin is in for a lung resection and Bron has developed a soft spot for him. She faces crisis upon crises as she hands in her resignation and her dear friend's life-saving operation goes terribly wrong. Connor doubts his ability as a nurse when a deranged patient takes a dislike to him. Von finds anger and compassion when a streetkid takes an unorthodox path to find help. Jared bears the brunt of Amanda's prejudices when she finds out that he could be HIV positive.

Steph steps into Terri's shoes as Nursing Unit Manager but alienates her colleagues with her demanding behaviour. Bron uncovers the shocking family secret that drove sisters apart 23 years ago when the sister of a brain-damaged patient insists her sister be allowed to die so she can receive an insurance payout. Luke is convinced his good relationship with Madsen is over for good when he risks a patient's safety by operating with an injured hand. Mitch and Kylie deal with a hypochondriac while Connor learns a lesson of the heart.