Connor is stunned to find Alana, a female patient, is a pre-operative transgender. His resolve to cope is shattered when he subsequently learns that she used to be his football coach, and a mentor after Connor's father died. Repulsed and betrayed, Connor wants nothing more to do with Alana. Nor can he understand how Alana's son Tom, also an old friend, can be so accepting of the situation. Alana is diagnosed with breast cancer as a result of the hormone therapy she is on. She refuses to have a mastectomy and will not stop taking the hormones, as it would mean returning to the body she felt trapped in all her life. Connor confronts her for being a coward. Surely any life is better than none at all? Tom helps Connor appreciate the significance and bravery of Alana's transformation. Her distress over the injustice of her fate and insistence that she is still the person Connor admired, finally makes him accept not only the choice Alana has made, but Alana as a woman.

While Steph worries about her husband, Ben enjoys the freedom of being a separated man by flirting with a woman he is called to attend. However, innocent banter suddenly becomes serious when the woman offers her his phone number and then a lift home. Ben succumbs, ending up in bed, only to regret it.

Von refuses to heed Mitch's constant nagging that she must adjust her lifestyle to accommodate her lupus. Her day is not made any easier by Colin, a flamboyant chef who refuses to change his long hours, copious drinking and rich diet despite his diagnosis as a diabetic. Von is finally forced to read the riot act to him and can no longer ignore the relevance of the lecture to herself. Mitch drives the point home. If Von does not look after herself, she won't be able to hold down her job — and her work is the only thing Von has in her life. She goes home to begin educating herself about coping with lupus.

Terri learns Mitch is seeing an employee at All Saints. She becomes totally preoccupied with finding out the woman's identity, finally discovering it is Juliette, a physiotherapist. Mitch's refusal to divulge anything only frustrates her further. Not only is she cool towards Juliette, she is also snappy with her staff. Terri can't believe she has become the victim of the green-eyed monster and resolves to pull herself together, offering Mitch her genuine blessings for his future with Juliette.

Jared is the only nurse to readily accept caring for an obsessive-compulsive patient. At first, he and Sharon get on well, sharing their liking for cleanliness. However, as Sharon's condition becomes more and more trying, Jared starts to recognises some of his own behaviour in her. He tries his best to fight his own 'tidy' instincts, but is destined to fail.

Terri's mother, Eileen, asks her for help when her husband (Terri's father), Ryan, bashes her. Eileen refuses to go to hospital and Terri asks Mitch to come to her flat to treat her. Mitch discovers Terri has never talked to her mother about the domestic violence. He urges her to persuade Eileen to leave Ryan. Terri tries, but all the years of pretence make it impossible for mother and daughter to be honest with each other. Terri thinks she can try again in the morning but when she gets up she finds that Eileen has gone home to Ryan.

Working a night shift, Von nurses Lillian Gehler, who has been in a car accident with her husband. Lillian is told her husband is in the Intensive Care Unit but she continues to ask why he does not come to visit. At first Von believes the woman's disorientation and anxiety are the result of the anaesthetic but she soon realises Lillian has no short-term memory. Von and Luke learn the memory loss is a pre-existing condition and was caused by herpes simplex encephalitis, and Lillian's husband was her primary carer. Von manages to calm her patient's anxiety. When she learns that Lillian's husband has died, Von has to break the sad news and share the woman's grief. Then, unable to remember even her own grief, the patient calls for Von again and asks when her husband will be coming to visit.

Ben and Bron attend a party where a young girl has collapsed after taking a cocktail of drugs and alcohol. Her student ID card identifies her as Zoe Dell. When Ben and Bron try to get her to hospital, they are confronted by a gang of drunken youths. They call for police back-up. The girl's condition worsens and they have to treat her while under siege. Steph believes the girl has been admitted with false ID and she clashes again with Dr. Preece, refusing to treat 'Zoe' as prescribed. Steph discovers the girl is really Julie Bentham and she is allergic to penicillin. If she is given the antibiotic she could die. Julie's life is saved twice in one night.

Connor is rushed off his feet when one of his patients reacts badly to a new sedative and starts to sleepwalk. Connor chases him around the hospital all night and falls foul of the night Assistant Director of Nursing Brenda Blair.