A young woman is raped and strangled on a Los Angeles beach. Further down the coastline a young boy is shot and arrested for her murder. Quincy doesn't think that it would have been possible for the boy arrested to strangle the woman and decides that he is going to go out and begin a little investigation of his own. He visits City Hall where the woman worked to ask some questions and, after a little checking, finds out that there seem to have been a rash of unexplained deaths there.

Quincy, Lee and Danny are all in Lake Tahoe together. Quincy is there for a forensic Pathologist convention and the others for a weekend break. While they are there the guests and staff start coming down with some kind of strange illness. Quincy and a couple of other Forensic Pathologists are called in to help but when some of the patients start dying they still have no clue as to what is killing them. To make things worse the casino owner does not want to admit that anything is wrong, as it will affect his bookings and profits.

The disease continues to spread and the rest of the hotel/casino's guests want to know what is going on. They want to get out of the building but Quincy and his colleagues know that they have to keep the disease, and the guests, contained. If the disease gets out of the hotel it could cause an epidemic that could quickly spread all over the country!