Gia, a grieving writer, sets out to write a book about female desire in America. She introduces us to three subjects: Lina, a homemaker in suburban Indiana; Sloane, a glamorous entrepreneur in the Northeast; and Maggie, a waitress in North Dakota.

Lina kicks off her flight from a stagnant marriage and a body of pain. She joins a women's group at Doctor Henry's, attempts to reconnect with the love of her life—her high school boyfriend, Aidan—and begins a friendship with Gia that will change both their lives forever.