In his efforts to try to get hold of all of the money Sucre runs into some unexpected difficulties. And Captain Bellick and his partner have not given up on finding their old inmates.

In an effort to learn more about his pursuer Michael cozies up to Mahone's wife. L.J. and Lincoln have a bumpy road-trip. T-Bag receives a surprise, and C-Note's wife must choose between her daughter and husband.

As Lincoln tries to reunite with Michael, he has to say goodbye to another loved one. Michael attempts to obtain a getaway plane. T-Bag gets revenge. Sara and Kellerman face-off.

Bellick is anything but happy about his sudden homecoming-to Fox River.Elsewhere, Michael and Lincoln might face a homecoming of their own. Mahone and Kellerman use everything they got to make certain that Michael and Lincoln do not get through their road trip alive.Sucre's getaway plane encounters some difficulties. T-Bag closes on Mrs. Hollander.

In Mexico, Sucre gets a car but gets in trouble by the police. Bellick has more trouble as the new inmate as prisoners who suffered with him want revenge.

T-Bag digs deep and finds his 'nice-side' with the help of a psychiatrist. Michael, Lincoln, and Sara get their hands on evidence needed to bring down The Company, while Kellerman is close to finding the President.

An unlikely alliance forms between Bellick and Sucre while Michael is determined to face the president. T-Bag gets into some trouble when he loses his luggage and C-Note faces major consequences after some of his actions.

Sara sacrifices herself for the safety of Michael so the brothers can get on with their final plan to attain freedom, but their plan gets 'shipwrecked'. Meanwhile, Bellick blackmails Sucre to partner up as T-Bag's streak of murder continues to the south of the border.