After being bitten by tiny green ghost beetles, the kids of Casper High get a mysterious illness that gives them ghost powers and are quarantined at a spooky old hospital outside of town. When Danny sneaks into the hospital to investigate, he is captured by Penelope Spectra and her assistant, Bertrand. They are the ones who started this illness as part of their plan to build Penelope a young and beautiful new body. All she needs is Danny's half-human/half-ghost DNA to complete her ghostly plan. With Danny captured and Sam sick, it's up to Tucker to conquer his fear of hospitals and free Danny before Penelope gets what she's after.

A group of ghostly skeletons under the command of a bratty 10-year-old pirate named Youngblood attacks FentonWorks and steals the ghost shield. Soon after, all the adults in Amity Park are packing for a cruise without their kids. Danny, Sam, and Tucker discover that the cruise is a hoax and the adults are under the spell of a mysterious (and cheesy) song created by Ember to make them into galley slaves for Youngblood's pirate ship! The stolen ghost shield prevents Danny Phantom from getting on board the ship, so Danny Fenton has to lead Amity Park's teenagers in a daring attempt to save their parents.

When Vlad Plasmius accidentally awakens the most powerful ghost of them all -- Pariah Dark, the King of all Ghosts -- Danny quickly finds himself the pawn in an action-packed, suspenseful game of chess. The only way to defeat the Ghost King seems to be a brand new Ecto-Skeleton battle suit that Jack and Maddie have constructed, but there's one big problem: wearing the suit can be fatal and only Danny can use it to defeat the Ghost King. With time running out, and the entire town of Amity Park sucked into the Ghost Zone, Danny Phantom must battle the all-powerful Ghost King to save his family, his friends, and even his enemies.

Danny and his friends get caught up in a time-traveling adventure. They are taken into a dark future, in which Amity Park is destroyed and the world's most powerful and evil ghost is Danny's own future self!

Technus is back! But this is a new and improved Technus, a smoother operator who refuses to shout out his plans. Danny's not worried, especially after he splits himself in two and decides to leave the ghost hunting to his super hero side and allow his teen self some time off to just be "normal." Unfortunately, Danny Phantom, super hero, begins to take his job too seriously and Danny Fenton, average teenager, starts to enjoy slacking off way too much. Meanwhile, Technus electronically infiltrates the Fenton RV -- and, then, all of FentonWorks -- siphoning off the energy to complete his upgrade. It's up to the two Dannys to work together and defeat Technus 2.0 before he drains all the power from Amity Park, and then the world!

Danny Fenton hates Christmas. When he accidentally destroys the only copy of a ghostly Christmas story, the book's author, Ghost Writer, makes Danny hate the holiday even more by turning him into the main character of a brand new Yuletide tale. Danny is now trapped in a scenario where everyone talks in rhyme! With his magical Quantum Keyboard, Ghost Writer creates a series of catastrophes that threaten to ruin Christmas for all of Amity Park and pins the blame on Danny. When Danny goes into the Ghost Zone to confront Ghost Writer, he is surprised to find his old ghostly enemies in a giving mood. Danny enlists them to help him defeat Ghost Writer and restore the spirit of Christmas to Amity Park and, perhaps, to his own heart.

Technus is back, with a new plan to beam himself up to a super satellite and take over the world, and he's going to use Axion Labs to do it. As Danny Phantom battles Technus, Danny Fenton begins battling his feelings for Valerie, whose dad is back in charge at Axion. Sam and Tucker are surprised when Danny confesses he's thinking of asking Valerie to go steady. Unfortunately, as Technus puts his plan into action at Axion Labs, Valerie realizes her role as ghost hunter is putting her family and friends in danger. Can romance work between two kids with secret identities, or will the ghost boy and the ghost hunter end up breaking each others' hearts?

Sam can barely contain her contempt for the "Miss Teenage Happy Princess" beauty pageant and its organizer, Dora Mattingly, when they descend on Casper High. She decides to enter the contest to make a statement about individuality, but makes a discovery instead: Dora Mattingly is the Dragon Ghost! Before she can get to the bottom of the mystery, she's inadvertently crowned Miss Teenage Happy Princess by its happy-go-lucky judge... Danny Fenton! When the tiara is placed on Sam's head, it magically transports her to a castle in the Ghost Zone, where she learns she's to be the bride of Dora's brother, the ghostly Prince Aragon. As Danny and Tucker head into the Ghost Zone to rescue Sam, she does her best to shake things up in the medieval ghost world she's stuck in.

Vlad's up to something and it involves Danny. After he sends three ghosts to Amity Park to battle Danny Phantom, it is revealed that he's working on his creepiest project yet: a clone of Danny Phantom. So far, the clones he creates can't sustain their forms for very long, but Vlad is determined to succeed. Danny doesn't have long to worry about Vlad's ghostly visitors, however, because he's distracted by the appearance of Danielle, a cousin he didn't know he had. And then, Danielle reveals that she too has ghost powers -- she's Dani Phantom! Unfortunately, she's also a product of Vlad's experiments, and therefore an imperfect ghost with an unstable form. Danny must convince his new "relative" to turn on her creator and help him destroy Vlad's evil experiment, before it's too late for both ghost kids.

The building boom in Amity Park upsets Undergrowth, the ghost of all things plant-like and vegetative. The green-thinking ghost takes over the town, turning everyone into plants themselves. All except Sam, that is, whom he makes his Earth-loving queen. Unfortunately, Undergrowth brainwashes Sam and uses her to attack Danny! Danny, meanwhile, has been battling a nasty case of the chills that leaves him too weak to fight. Escaping from Undergrowth in the Ghost Zone, Danny turns to his cold-loving friend, Frostbite,who explains that Danny is developing a new power. Now, Danny must learn to master his new freezing skill so that he can make his way back to Amity Park and pull the town out of Undergrowth’s leafy clutches.

Amity Park is in the midst of a drought, and Mayor Vlad, eager to score points, releases Vortex, the weather ghost, to make it rain. But when Vlad double crosses Vortex, the ghost conjures a storm that threatens to drown the town! As Danny Phantom flies to the rescue, he’s zapped by a lightning bolt. When he comes to, he discovers that his emotions are now directly tied to the weather!

As one of the weakest ghost in the Ghost Zone, the Box Ghost attacks with every "deadly box" he has in the human world, but is easily defeated by Danny. He then makes a plan: he will use "Pandora's Box", the most powerful box ever created, and will use the evil and deadly powers inside it to attack Amity Park. Now Danny must find the only one able to save the day: Pandora herself!

Danny, after being publicly shamed by Vlad's new ghost hunting team, wants to be normal again. So he gets rid of his powers by reactivating the Fenton Portal after Jack dismantles it for a software upgrade. However, an asteroid made of Ectoranium threatens the Earth, and Vlad - after revealing to everyone that he is Plasmius - fails to stop it. The world now relies on a powerless Danny to get help from the ghosts in the Ghost Zone!