Pam accidentally brings lice into the office and lets Meredith take the fall, while Dwight vows to destroy the parasites. Meanwhile, Jim has a fantastic day in Philly wooing a potential business associate. Meanwhile, Phyllis, Nellie and Kevin meddle in Darryl's love life.

Dwight becomes regional manager after Andy quits his job, Jim dedicates more time to his Dunder Mifflin job to save his marriage, and Angela has problems with her new living arrangements after her breakup with The Senator.