Today is the first day of the rest of Earl Hickey's life. After coming into a $100,000 scratch-off lottery ticket and losing it just as fast upon being hit by a car, Earl has an epiphany in the hospital--to make up for all the terrible things he's done in the past. With his brother Randy and a motel maid named Catalina, Earl writes up a list of every misdeed he was a part of. Earl sets out to do just that, starting with #64--Kenny James, a boy he picked on in elementary school.

Darnell and Joy decided to tie the knot while Earl learns thru Randy’s invitation that he is not invited. To make things worse Joy has scheduled the wedding on Earl’s birthday so that all of their friends will be unable to celebrate with him. A drunken Earl crashes the party accidentally breaking Joy’s nose and now is forced to add “ruined Joy’s wedding” to his list.

It's Mother's Day again when Earl remembers that he has never given his mother a Mother's Day gift Just as he and Randy are about to finish carrying out his long overdue gift his mother decides her repayment should include Earl doing something for his father.

Earl attempts to cross out number 147 on his list "Shot Gwen Waters with a BB Gun." To make things right he must reunite Gwen with her estranged father which Earl finds increasingly difficult.

In the season finale, Earl decides to cross off the first number on his karma list, “Stole ten dollars from a guy at the Camden Market.” Earl to his dismay finds out that he owes much more than ten dollars, in fact he must surrender all his lotto winnings. Earl now ponders when karma is going to help him with his misfortunes.

It's a trip down memory lane for Earl, Randy, Joy, Darnell and the Crab Shack regulars when they remember their fifteen minutes of fame watching a 2003 repeat of the TV show "Cops," which was filmed in Camden County.

Earl takes on number 101 on his list, "Stole a girl's identity." The girl turns out to be Joy's half-sister that she never knew about and the one person that could possibly help her get sympathy from the jury. The problem, Joy and Liberty are enemies.

As Earl and Randy work to cross No. 29 on the list "Harassed A Reporter," Randy gets tired of being in his brother's shadow. In an attempt to distance himself from his brother, Randy realizes the true power of karma and the media.

Joy visits Earl in prison and they are surprised to meet an old friend who is also in prison. The three reminisce about their past and how they met.

Earl and Randy watch the filming of Cops in Camden County where the different situations are slightly related to Earl. Meanwhile, Kenny's hatred for Earl is caught on camera.

When the hospital wants to get rid of Earl, Randy decides to take care of his brother by himself. But instead of working on the list for Earl, he uses Earl's help to cross things off in order to help him get better.

When Joy cons Make-A-Wish to send a celebrity to her trailer, Earl remembers a wish he stole from a dying child and decides it's time to cross him off the list. When he returns to the kid's home, he finds that little Buddy has exceeded all of the doctors' expectations and is still alive. Buddy asks Earl to produce his movie and suddenly all of Camden County find themselves starring in a high-octane action film. Randy surprises everyone when his acting skills get rave reviews.

Earl and Randy decide it's time to make amends with their childhood neighbors, the Clarks. But when they discover more skeletons in the closet than they had expected, the brothers find themselves needing to sort out some family issues between their mom and dad. Meanwhile, Joy has duped one-eyed Willy out of his glass eye, and despite Darnell's efforts Willy may never "see" that eye again.

Earl remembers his first wedding anniversary and the events that finally lead to their break up, involving Earl's cousin Blake and an invasion of killer bees.

Earl loses his list while tornado's hit Camden County. Meanwhile, Randy thinks he's invincible after a wild boat ride and contemplates how he should use his new found power. Elsewhere, who's the smartest, Joy or Darnell? that's what this weeks argument is about and Catalina and Patty have a religious awakening.

Earl works on a list item that deals with a crazy witch lady. Meanwhile, Joy wants to show Darnell her good side.

News show "Inside Probe" investigates the disappearance of the Crab Shack owner. After eight years the show airs on TV, and several Camden residents become murder suspects.

The mystery of the disappearance of the former Crab Shack owner is finally resolved.