Kim and Ron visit a strange man by the name of Lord Monty Fiske, however, they soon realize that there is more to him. Meanwhile, Kim's geeky cousin comes to Middleton.

Kim is forced by her dad to join a club for small children that he leads, much to her dismay. Meanwhile, Monkey Fist plans to steal a very special monkey to fulfill a prophecy.

When Kim catches a cold from her brothers before a mission, she soon discovers that it’s hard to save the world when you’re not feeling well. Dr. Drakken and Shego exploit the moment to steal a laser from the research lab Kim is guarding. However, when Kim’s sickness begins to spread, a series of events occurred that not even she could expect.

Yori’s sensei has been kidnapped and all evidence indicates that Lord Monkey Fist is responsible for it. Yori comes to Middleton to get Ron, in which Yori and Ron head off to South America to attempt to stop Lord Monkey Fist. However, when Kim starts to grow suspicious about Yori’s sudden appearance in Middleton, she heads after them to get to get to the bottom of their predicament.