Ed, Danny, and Mike combine forces with the investigative team of Dr. Jordan Cavanaugh and Det. Woody Hoyt to solve the murder of a high-stakes gambler. The mystery intensifies when it appears that the gambler's wife may not be the only woman who wants him dead. Meanwhile, Snoop Dogg is trying to convince Delinda to allow the Montecito to be the site of his next music video. Elsewhere, Ed must deal with the demands of his wife Jillian, who has moved into the Montecito while their house is being renovated.

The crossover starts on Crossing Jordan S04E07 What Happens in Vegas Dies in Boston (I).

Danny is with blackjack player Gabe Labrador who's wearing a wig and counting cards. The man doesn't want to stop playing and claims he must win big to pay off the men who kidnapped his daughter. Ed, Mike, Danny and a cop from Metro work on the case even though they aren't sure Gabe is telling the truth. Mary seems to still be helping Danny taking care of his dad's stuff. She is still dating Jake. A player who won a lot of money wants to give it back, but then wants it back, then wants to give it again, etc. Sam and Woody (from "Crossing Jordan") are getting very well acquainted... Jordan from "Crossing Jordan" is also in this episode.

Excitement's in the air at the Montecito when Olympic athlete Sasha Cohen stops by. Delinda gives Derek an answer to his marriage proposal. A couple big gamblers enlist Danny and Mike to investigate whether their spouses are cheating. Sam and Woody take off for a romantic weekend.

While Delinda is preparing to get married old romances resurface. Bachelor and Bachelorette Parties are being planned. Meanwhile Ed is being visited by his CIA past.

This is another cross-over episode with Crossing Jordan. Woody and Jordan are in Las Vegas to investigate the murder of a violinist and the disappearance of his Stradivarius. The Montecito's safe-deposit vault is being robbed.