When Chief of Internal Medicine Dr. Amy Larsen suffers a catastrophic brain injury, her life is turned upside down. Still determined to once again practice medicine, she charts a new path forward, ready to face whatever obstacles stand in her way.

While at the hospital recovering, Amy can’t help but insert herself into her roommate’s case. Meanwhile, all the other doctors and nurses have to adjust to the once formidable Chief now being the patient.

Amy, allowed to return to work under strict guidelines, teams up with TJ to treat a patient suffering from mysterious liver problems. Sonya and Jake help an elderly couple navigate the final chapter of their love story.

Amy and Richard reconnect while treating a patient whose diagnosis is not at all what it seems. A real life romcom comes to Westside Hospital, bringing love to the forefront of everyone's mind.

Amy, finally allowed to practice medicine again without supervision, struggles to diagnose her most complicated patient yet: TJ’s Dad. Sonya and Jake treat a single mom who’s reluctant to stay in the hospital. Richard tires to contain the truth about Dixon.

A mass casualty event requires all hands on deck at Westside Hospital. Amidst the chaos, Gina deals with a devastating revelation and Amy’s forced to confront her demons.