Patrick Kent, a Vice-President of a New York investment-banking firm, vanishes from a San Diego airport, only leaving behind two empty suitcases.

Delia , a television reporter, disappears in the middle of the investigation of a nightclub owner who is a suspected drug dealer. They also discovers that Delia was working on the case of a murderer on death row who she thought was innocent, and who might be linked to an assistant district attorney working with Jack on the case.

The team find themselves up against the ropes as multiple mysteries arise in the case of a boxer. Dante Jones disappears moments before a bout with a $500,000 purse that which could have made him a title contender. Jack suspects it's stunt, but Vivian, a Jones fan, can't believe that the charity-loving, straight-arrow fighter would go doewn that low road. The search goes in a new direction when his younger brother who he is always bailing out of trouble, vanishes. Then it's learned he has made 2 million dollers in the past five years,but he only has $6000 in his bank account.

A missing-persons case becomes a criminal investigation when, after a recently engaged woman disappears, it turns out that she was running a confidence scheme.

When a female ex-cop-turned-bounty-hunter is shot then goes missing the team must investigatesher were about's

The team searches for a mother and her two children, who are last seen boarding a yacht which is later found adrift in New York's Harbor with only its dead captain aboard. Meanwhile, Malone gets ready to leave the team and move with his family to Chicago.

This time, the team searches for a delusional appearing Sci-fi fanatic who disappeared from his appartment after ranting on about those ""out to get him"" (before peeling back the tinfoil covering his windows). Jack also has to deal with the consequences of his actions in the affair and how it affected the rest of the team.

When Ian Norville disappears on a field trip to a museum in Manhattan, the team gets involved, but it isn't long before Jack turns his suspicion to his father, Daniel, who soon admits that he didn't take the necessary precautions with his son, who happens to be autistic.

Danny is skeptical when the pregnant girlfriend of his missing estranged brother, Rafael ""Rafi"" Alvarez, and mother of their 9-year-old son, tells him that Rafi has transformed himself into a responsible family man, who recently obtained a loan to open his own body shop. But Danny's investigation uncovers that Rafi has been seen with a convicted car thief, and the large sum of cash he'd been flaunting for his purchase of a body shop didn't come from the bank. Though Jack makes the point that Rafi may have legitimate explanations for the suspicious circumstances, Danny braces himself for the very real possibility that his brother may have put himself in harm's way.

Jack finds himself in the hotseat when a young white woman and a young black man, go missing on the same night and Jack is ordered to put more of the team's resources into finding the young woman.

The team searches for a missing mother who they believe may be searching for her son, who is also missing.

Malone's team joins forces with Gil Grissom, a CSI from Las Vegas, and his team as they track a serial killer with ties to New York.

The crossover starts on CSI: Crime Scene Investigation S08E06 Who and What (I).

Jack goes missing after taking a case into his own hands which soon becomes intertwined with a human trafficking prostitution case that Vivian is working on.

Five people with an odd connection go missing from a coffee shop, and the team determines what the connection had to do with their disappearance. Meanwhile, Samantha gets ready for the birth of her child.

Jack and Samantha head to Los Angeles to look into the disappearance of a man who vanished after attending a funeral.

The team believes that the past of a missing psychologist's brother might have played a role in his disappearance. Martin's relationship with Kim takes a spicy turn.

The team searches for a man who goes missing after a late night dive and try to zero in on who could be responsible for his disappearance. Meanwhile, Danny and Elena take their relationship to another level.