Bubo Bambara kidnaps Dr. Fujinami and forces him to do research on Bambacteria, his energy source. He plans to exterminate the entire human race. The doctor escapes, taking the bacteria with him, but Bubo Bambara outwits him. Sanagiman has his hands full fighting a Bubo Bambara who is now a million times stronger…

Gale Bambara sends a dump truck flying with a blast of wind. Shinichi, the driver, is saved by Raijingo, but his truck is badly damaged and Shinichi can't afford to have it repaired. A man, who is actually Gale Bambara, tells him that the accident was caused by Raijingo. Shinichi tries to damage Raijingo by ramming it with his truck…

The runways at Haneda Airport have suddenly turned into sand, and landing planes are swallowed by quicksand. Raita, who has witnessed Sand Bambara in action, is swallowed up too, but Inazuman saves him by psychokinesis. Raita thinks he was saved by his own psionic powers. Sand Bambara believes that too, so he snatches the boy…

When a huge explosion occurs at a petroleum complex, a young girl falls under suspicion. Satoko and the others believe she is innocent and hide her. The girl has lost her memory and can't even tell them her name, but Goro is suspicious. She is being manipulated by Oil Bambara. When Inazuman is injured later, he is cared for by the girl…

A UFO is spotted in the mountains. Goro and the kids investigate and save Arisa, who is attacked by Fog Bambara. Arisa disappears after stealing Katsumi's photo of the flying object. Eventually, Arisa comes to trust Goro and tells him Fog Bambara's plans. The UFO is the Neo-Human Empire's bomber and they plan to attack Tokyo…

Goro investigates reports that Neo-Humans have been gathering construction workers. Suddenly, a building explodes; it is a secret Neo-Human plant where those workers are being forced to work. Mamiya, the only survivor, is too badly injured to return to his family. Goro goes to find his family, but is badly injured by Thorn Bambara…

Joji has the power to foresee the future. Poison Bambara captures Joji, who has predicted the Neo-Humans' terrible plot. Joji uses his telepathic powers to summon Inazuman, who advises him never to use telepathy again, for it would drain his energy. But when Inazuman is blinded by Poison Bambara's toxic gas, Joji must make a decision...

DES Missle, Great Mid-air Battle is the fifth episode of the Inazuman Flash tokusatsu series.