With an entire town after the bounty on his head, Vash must contend with the dangerously destructive Nebraska Brothers - while saving the very same villagers who are bent on bringing him in!

Things get complicated when the gang gets tangled up in the drama surrounding a runaway dancing girl and the son of a caravan owner.

A flashback offers a glimpse into the distant past of Vash the Stampede, his brother, Millions Knives, and the enigmatic Rem Saverem.