The Roderick gang’s battle with Legato is violently interrupted by the fierce Gung-Ho Guns. Just as Vash begins to investigate the incident, he meets Dominique the Cyclops, a lethal beauty with an amazing power.

With reports of new Vash sightings, Meryl returns to the work of tracking him down. Meanwhile, Vash and Wolfwood make their way to a town where a family feud has escalated into a hostage situation.