Ira is full of sexual energy thanks to the new hormones he's taking - but when he learns they are really placebos, he proposes to Holly. Cybill agrees to be Ira's best man, but when Zoey resists being a bridesmaid, Holly shows her true colours. Meanwhile, Maryann goes to confession.

Cybill becomes a prime-time hit in the new sf series Lifeforms, but when her co-star starts sleeping with the female producer, Cybill's role gets reduced to a few lines per episode. Meanwhile, Ira tries to convince Zoey to throw a bridal shower for Holly.