Joel (Fred Armisen) rambles endlessly about a restaurant he visited to his friend Liz (Kristen Wiig) at first, and becomes so involved in the story, he fails to notice that he is discovered by talent scouts (Bill Hader, Parnell), stars in a movie with Scarlett Johansson, becomes a national phenomenon and then loses it all when his movie flops at the box office. Brian Williams, MTV correspondent Gideon Yago, and Conan O'Brien also make cameos.

In a frame story, Hader and Samberg pitch their new ultra low-budget Digital Short, Laser Cats! to SNL executive producer Lorne Michaels. In the Laser Cats! short itself (a short within a short), Hader and Samberg play the heroes Nitro and Admiral Spaceship in a post-nuclear war world in which cats can shoot lasers from their mouths and are used as weapons. They are saving the princess (Lindsay Lohan) from the evil Robotron (Will Forte). Rachel Dratch makes an appearance, disguising herself as the princess/Lohan. Jorma Taccone appears in the opening credits for Laser Cats! Fred Armisen also makes a cameo. Laser Cats! is shot in the SNL offices (this is done with intended obviousity, as the short is supposed to be "low-budget").

New office employee Gary (Hader) gets into a fight to the death with incumbent cubicle holder Steve (Dane Cook). Sudeikis appears as the boss and Samberg, Forte, Armisen, Thompson, Poehler and Wiig are other employees cheering on the fight.

In the same frame-story format, Hader and Samberg apologize to Lorne Michaels for the original Laser Cats! claiming to understand where they went wrong: not enough politics. They then introduce Laser Cats! 2, based on the same premise, now set in the Iraq War which has gone nuclear and caused the feline mutations. This time, Dr. Scientist (Jake Gyllenhaal) has stolen the cure that turns Laser Cats back into regular cats. Jorma Taccone appears in the opening credits for Laser Cats! 2 (Which is the same as Laser Cats!), and Fred Armisen and Amy Poehler are the scientists who created the cure.

An old man presents films which have his grandsons (Hader and Samberg) digitally inserted in order to help old people be more comfortable with today's films. Features clips from the films No Country for Old Men, Michael Clayton, Juno, Transformers (referred to as "The Transforming Robots"), and There Will Be Blood.

Samberg and Hader are at a party where everyone and everything is a literal representation of a slang term.

Samberg and Hader once again try to persuade Lorne Michaels with another Laser Cats! movie with some "help" from James Cameron (appearing as himself).