New office employee Gary (Hader) gets into a fight to the death with incumbent cubicle holder Steve (Dane Cook). Sudeikis appears as the boss and Samberg, Forte, Armisen, Thompson, Poehler and Wiig are other employees cheering on the fight.

In the same frame-story format, Hader and Samberg apologize to Lorne Michaels for the original Laser Cats! claiming to understand where they went wrong: not enough politics. They then introduce Laser Cats! 2, based on the same premise, now set in the Iraq War which has gone nuclear and caused the feline mutations. This time, Dr. Scientist (Jake Gyllenhaal) has stolen the cure that turns Laser Cats back into regular cats. Jorma Taccone appears in the opening credits for Laser Cats! 2 (Which is the same as Laser Cats!), and Fred Armisen and Amy Poehler are the scientists who created the cure.

A corporate executive (Rainn Wilson) leads a meeting to take ideas on how to save his failing company, and hears suggestions from an increasingly bizarre set of employees, including a gigantic turkey sub and Arcade Fire. Upon reaching the end of the meeting, Wilson receives a phone call, seemingly informing him that the office building is about to be blown up. Then, the office building explodes, killing all of them inside. Amy Poehler, Bill Hader, Jason Sudeikis, Kristen Wiig, Will Forte, Darrell Hammond, Fred Armisen, Maya Rudolph and Andy Samberg all play employees of Wilson's, and Kenan Thompson plays a water guy.

In a spoof of The O.C. episode "The Dearly Beloved", a man (Hader) writes a letter to his sister, he is shot by his friend (Samberg), leading to a series of overly dramatic, slow-motion shootings set to "Hide and Seek" by Imogen Heap, including their roommate (Shia LaBeouf), the sister (Wiig), and two police officers (Sudeikis, Armisen).

An old man presents films which have his grandsons (Hader and Samberg) digitally inserted in order to help old people be more comfortable with today's films. Features clips from the films No Country for Old Men, Michael Clayton, Juno, Transformers (referred to as "The Transforming Robots"), and There Will Be Blood.

Jonah Hill confesses to Samberg about how he has fallen in love with his father, Ben Samberg (played by longtime SNL writer Jim Downey). Hader also confesses the same thing.

Samberg and Hader interrupt Lorne Michaels' dinner with Christopher Dodd (appearing as himself) to attempt to pitch Laser Cats! again, this time with a scene enhanced by 3D glasses. The plot revolves around a ban on all laser cats and a battle against the corrupt Mayor Top-Hat (Thompson). Christopher Walken appears as a general.

Samberg and host Shia LaBeouf sing a high-energy country song for an infomercial about Samberg's new dress shirt, black socks, no pants look (the best look in the world). Armisen, Forte, Thompson, Sudeikis, and Hader all appear as people following the trend (a dad, a husband, two cops, and an illiterate genie).

Ricky Gervais presents a clip from a Japanese show that was his inspiration for The Office, featuring Japanese versions of Michael (Steve Carell), Dwight (Hader), Jim (Sudeikis), Pam (Wiig), and Stanley (Thompson). Also, Darrell Hammond plays Regis Philbin in a tampon commercial. At the end of the episode, Gervais comments "It's funny 'cause it's racist".

In the year 3022, an alien (Andy Samberg) sings about the Space Olympics, a sporting event on a distant planet where athletes from all over the universe compete for gold medals until budget cuts result in some serious problems.

In a clip from Paul Rudd's new movie, Samberg romantically paints him nude and then Rudd returns the favor (A parody of the film Titanic). While selling the painting at an auction, it is shown to be so graphic that everyone who sees it begins convulsing violently, vomiting, bleeding from the eyes, and committing violent acts of suicide. Fred Armisen appears as the auctioneer, Bill Hader and Kristen Wiig as Indiana Jones and Marion Ravenwood respectively (parodying the ending of Raiders of the Lost Ark), and Casey Wilson as the interviewer.

Neil Patrick Harris and the Doogie Symphony Orchestra present, the Doogie Howser Theme Song.

A "half human, half Laser Cat, half RoboCop" named Cyber-Face (Kenan Thompson) is presented to a group of scientists by their colleague (Will Forte) but quickly goes haywire. Admiral Spaceship (Samberg) and Nitro (Hader) intervene to put an end to its killing spree, and are shocked to find out that Cyber-Face is Admiral Spaceship's estranged father (Martin) right before he is gunned down by police officers.

Samberg blackmails the Jonas Brothers with a videotape of them as an '80s band called Property of the Queen. Samberg ultimately wants to know how they stayed young for 25 years and it is revealed that the wizard featured in one of their music videos (Bill Hader) kept them young. Kenan Thompson, Will Forte, and Bobby Moynihan appear as band members.

Samberg and Hader are at a party where everyone and everything is a literal representation of a slang term.

During a performance review conducted by episode host Seth Rogen, Samberg raps about his typical day as the boss of a large company.

In this parody of the movie adaptation of Twilight, a high school girl (played by host and musical guest Taylor Swift) falls for Frankenstein's monster (played by Bill Hader).

Samberg and Hader once again try to persuade Lorne Michaels with another Laser Cats! movie with some "help" from James Cameron (appearing as himself).

In a loose parody of Sam Raimi's Drag Me to Hell, a young businessman (Samberg) is cursed by a homeless shaman (Fred Armisen) to be haunted by a sexy, shirtless saxophonist named Sergio (played by host Jon Hamm) after stepping on the shaman's dreamcatcher and not paying for it.

A man named Kyle (Ryan Phillippe) keeps knocking on his loved ones' (ex-girlfriend, best friend, parents, etc.) doors to find that they are romantically involved with a man with a bizarre European accent (Samberg).

An unemployed cocaine addict named Dennis (Samberg) goes on drug binge while singing an elaborately choreographed Disneyesque musical-theater number about how it is going to be a great day.

Katy Perry sings at an Academy Awards-like ceremony the theme song from the fictional superhero film Boogerman (played by Peter Sarsgaard). Features most of the cast including episode host Amy Poehler.

In this "SNL Digital Short," winners of a Model U.N. competition (Andy Samberg) and Arcade Fire encourage the General Assembly to dance for world peace.

A parody of the movie Weekend at Bernie's, in which two men (Hader and Samberg) find the corpse of their boss (played by episode host Robert De Niro) and attempt to make him look alive during a party at his beach house.

Hader and Samberg again use a celebrity (Tom Hanks) to pitch a new Laser Cats film to Lorne Michaels; this time, a musical version which includes parodies of Cats and Spider-Man: Turn Off the Dark.

Two cops (Hader and Samberg) bored at work find music in everyday life (parody of Stomp).

Despite Lorne Michaels' objections, Hader and Samberg show him the latest Laser Cats short – this time directed by Steven Spielberg (appearing as both himself and a "Hitchcockian" cameo in the short), which contains many references to his films, including E.T. the Extra-Terrestrial, Close Encounters of the Third Kind, and Raiders of the Lost Ark. Host Josh Brolin appears as a "Space Nazi."

Andy Samberg and Adam Sandler sing about times when people broke character on the show.