After stopping a fatal battle with Hajime Saito, a top government official asks Kenshin's help in killing a shadowy assassin who's threatening the future of the regime.

While preparing to give his decision on helping to kill Shishio, Kenshin learns of the Home Minister's murder.

Kenshin's final effort to win the ultimate battle ends with Shishio destroying himself. But in the wake of Kenshin's victory, Shishio's closest aide vows revenge.