When MacGyver is on his way to a vacation, he takes the wrong way and ends up at a small airstrip where everybody seems to be behaving strangely. Too late, he discovers that the airstrip has been taken hostage, and he has been caught in the middle of a plane-hijacking attempt.

During a trip to visit some friends, an accident starts a fire in an oil well owned by MacGyver's friends. MacGyver and his buddy then go to fetch dynamite in an abandonned mine at great peril to themselves after they decide the dynamite is the only feasible way the fire can be put out. However, when they use it, the fire only becomes more intense. Can MacGyver and his Hellfire friend survive the incredible heat to put out the fire and save the oil buried underneath the well?

After blowing away a nuclear facility under the control of an aggressive world leader, MacGyver returns home for some peace and quiet, only to find his boss waiting for him. He advises MacGyver that a contract is out on his life and he needs to skip town for awhile.

When MacGyver comes home with some important documents, he's drugged by enemy agents and told that he will die in six hours if he doesn't retrieve the documents for them. But MacGyver, using an old prisoner trick, escapes. Now the only problem is convincing someone that he's not just another drunk.

An old girlfriend of MacGyver's contacts him for help after she discovers evidence of uranium thefts from a nuclear processing plant where she works.

MacGyver is on his way out of Bulgaria with a secret microfilm, when he meets Penny Parker, a beautiful, talkative American, who is on the run from her lover, a man named Stephan Frolov. She stashes some jewels on MacGyver, thus making him a suspect, and now MacGyver and Penny must flee Bulgaria together.

A 15-year-old genius accidentally hacks into a defective missile guidance system and attracts the attention of both the FBI and some black marketeers, who think that she may fix it for them. It's up to MacGyver to save her from being kidnapped by either side.

When a mother superior at a religious mission in North Africa asks MacGyver to help a young woman with something, he is glad to help. However, when he finds out the young woman wants him to break her brother out of jail, he may have taken on more than he expected.

Posing as a watchmaker who manufactures bomb timers, MacGyver manages to catch a master killer—Piedra—before he attempts an assassination on a high-profile target. However, Piedra isn't about to be stopped for long.