Gorgon is searching for Medusa to return her to the mysterious Great Refuge. Johnny is forced to help her, but Gorgon captures her. The Fantastic Four discover his hideout and find the Inhumans.

The Inhumans teleport back to the Great Refuge, but Johnny is teleported there too after jumping in after Crystal. The rest of the team try to find him, while it is learned Black Bolt's evil brother, Maximus, has taken over.

The Impossible Man is on the run from Super Skrull. Johnny agrees to protect him if he tells Lockjaw to teleport him to the Great Refuge to see Crystal.

Sue insists the team get some R, but Johnny stays at home. The others head to Tee Vu island, which is home to a Kree Sentry. Meanwhile, Black Bolt destroys the negative barrier and frees the Inhumans, reuniting Johnny and Crystal.

Doctor Doom once again makes himself all-powerful by draining the Silver Surfer's powers. Do the Fantastic Four have any hope of defeating him this time?