A nuclear explosion caused by Doctor Doom causes the Fantastic Four to lose their powers. Reed's efforts to restore their powers is cut short after Doom takes over the Baxter Building. The team will need the help of Daredevil to retake the Baxter Building and get their powers back.

Reed discovers a strange ""goop"" that can affect people's emotions. It comes from the Micro Verse and Psycho Man wants it back. He captures Sue, making her into Malice, Mistress of Hate.

Sue needs life saving surgery and only her father can perform the operation, but he has been in hiding for years since being accused of murder. When he comes to help, he gets arrested after the operation. Meanwhile, the Skrulls release Super Skrull, who takes Franklin Storm's place to exact revenge.