While on assignment, agent Michael Westen gets a "Burn Notice" and becomes untouchable. Having no idea what or who triggered his demise, Michael returns to his hometown, Miami, determined to find out the reason for his sudden termination.

A doctor seeks help when drug dealers terrorize his clinic; Michael is drawn into a game of cat and mouse with a killer.

Michael has to balance his new agency duties and helping a woman recover her cousin, who is one of many being trafficked into the U.S. by the Yakuza. Against Michael's wishes, Madeline becomes a critical component of the plan to find the girls.

The CIA abandons Sam after he goes undercover with a heroin dealer while trying to recover a weapon. Meanwhile, Pearce continues searching for Max's killer.

Michael is accused of a crime at a local hotel. Elsewhere, Olivia questions Sam in an attempt to get to Michael.