A group of friends from Chicago begin their annual fantasy football league by preparing the league draft, but three-time defending champ Pete has a problem: his wife Meegan doesn't want him to play this season.

Pete's split with Meegan intrudes upon Ruxin's marriage, as Sofia is neglecting him sexually in order to spend her time helping Meegan deal with the break-up. Meanwhile, Jenny reveals to Sofia the sexual secrets that ensure that Kevin will never leave her.

Andre plans an extravagant trip to Vegas for the league's 2010 fantasy draft, but the group credits Pete to mess with Andre. The gang must choose between Jenny and Ruxin's creepy brother-in-law, Raffi, when a spot on the league opens up during the trip.

Andre brings in a new partner to expand his medical practice. Ruxin uses a sick kid to meet NFL star Josh Cribbs and Pete deals with the complications of dating Kevin's ex-girlfriend.

Ruxin throws Sofia an anniversary party on the same day as Jenny's birthday. Meegan returns with a 'plus one.'

Andre and Ruxin refuse to accept a tie, adding to Kevin's current frustrations as league commissioner. Pete has a connection for great Bears tickets, but the gang warns him about what he may have to provide in return. Taco discovers Western medicine.

It's high-school reunion time, and Andre is looking forward to basking in his success while Ruxin wants to show off Sofia. Meanwhile, Pete needs a name for the new Last Place Trophy and everyone learns the history of the Shiva blast.