Sam discovers that Nicole, Poppy and Mary Cherry stole the answers to the biology midterm, and she sets out to gather the evidence she needs to turn them in. Meanwhile, Mike and Jane's sneaking around angers Brooke and Sam.

Sam gets a chance to produce a segment on a syndicated TV show--with one catch--Brooke is the on-air talent. Meanwhile, Josh must tell his father that he can't make a dinner with college scouts, which is scheduled for the opening night of the musical; and April Tuna becomes obsessed with Carmen.

Harrison campaigns to save the job of the school's shop teacher when the instructor's career is jeopardized by his announcement of plans for a sex-change operation. Meanwhile, Cherry Cherry teaches a home-economics course at Kennedy High as part of her community service sentence for punching a police officer.

Nicole, desperate to get back to the Glamazons, tries to bribe and blackmail Principal Krupps. Her attempts fail and she gets Mary Cherry and Sugar Daddy to help her make a fake video about him. As a result, she gets terminated from the cheerleaders forever. A new kid joins Kennedy High and gets a spot on the football team. Josh, jealous of him, tries to put everybody else against him. He gets his mom a job at school and she starts to date the football coach, and Josh's life falls apart. Sam misjudges George but realizes that friendship is more worth than an article. Josh finds Nicole crying, a proof that she still has a human side. They console each other.

Sam decides to take her relationship with George to the next level, and he gets scared and says they should wait until they're both ready. Bobbi Glass decides to make all her students act in a play she wrote herself (""That Burning Sensation: A Cautionary Tale"") about STDs, as a part of the ""National STDs Week"". The students are cast: Lily as gonorrhea; April as syphilis; Josh and SD are worrisome warts; Mary Cherry and Nicole are crabs; Brooke is herpes; Carm is unsightly yellow discharge and Sam gets the part as the whore, with Harrison (now back at school) as the lonely virgin. Josh and Sugar decide to give Harrison a ""virgin certificate"", since he is the only virgin boy in the group, but he gets offended and embarrassed. Instead of taking the certificate, he decides to ask Nicole to sleep with him, but she says no. so he decides to use his certificate, but the prostitute is so old that they decide just to have Chinese food instead. Lily runs into George at a clinic and finds out he

With a lot of power in her hands and not so many brain cells in her head, April Tuna is ordered by Principal Krupps to cut one of the school's clubs. April becomes an easy prey for Evil Nicole (still out of the Glamazons and thirsty for revenge), who manipulates her into cutting the Glamazons off. April and Emory have a small fight when she threats to cut the ""John Travolta-inspired Staying Alive"" club, for which Lily, Harrison and Josh compete to be president of. Meanwhile, Brooke gets in deep trouble after she doesn't come home from Jamie's, which causes Mike to get furious and ground both Sam and her for lying. After Jane talks to him, he finally decides to give Jamie a chance and invites him over for dinner. Back at KH, Emory blackmails Tuna in order to save his club, and she ends up losing the position of student body president to Nicole, who immediately cuts the Glamazons, replaces it with ""Bring It!"", the new pep squad with her as the big star, and shuts the John Travolta club,