The doctors join together for a celebration at Addison's house and to reminisce about the past. Meanwhile, Sheldon counsels a suicidal patient who comes forward with a shocking confession.

Sheldon fears the worst when a little girl goes missing from the ER; Addison and Jake have a disagreement about one of his patients; and a new doctor joins the team at Saint Ambrose. Meanwhile, Stephanie questions Sam about his past with Addison.

During a dark moment in his life, Sheldon finds happiness with a new woman. Meanwhile, he becomes increasingly suspicious about his patient Nick's involvement in Sarah's disappearance.