Casshern awakens to find his world reduced to a corrosive wasteland. Lost in a future he does not recognize, he struggles to stay a step ahead of those who wish death upon him.

An encounter with the mysterious Lyuze offers Casshern a fragmented glimpse of his role in the Ruin. After stumbling upon a community of “dying” robots, he discovers the true depth of his infamy.

Akoes warns Casshern against a life spent running from the past. When Friender arrives to make the assassin pay for his sins, Casshern chooses a path that could terminate his own existence.

The search for Luna leads Casshern and Friender to Margo, an artist who refuses to let the Ruin destroy his spirit. Casshern finds inspiration in the artist’s vision, but there are those who would rather see him dead.

Beautiful Sophita is feared by robots who wish to live as long as their decaying bodies will allow. Fighting makes her feel alive, and Casshern’s special abilities make him a foe she could fight forever.

Casshern and his traveling companions befriend three children claiming to be descendents of Luna. When the youngsters are attacked by Leda, Casshern risks his own life to protect them.